The detail information of Dermoid sinus
OMIA Basic Information

Possible human homologues (MIM numbers): -

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Dominant

Considered a defect: yes

Year key mutation first reported: 2007

Species-specific name: ridge; hair ridge

Species-specific symbol: -

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB204 Rhodesian Ridgeback 63.5-68.6 cm (male), 61-66 cm (female) 38.6 kg (male), 31.8 kg (female) Zimbabwe
Associated Gene
Symbol Description Species Position Other Links
FGF4 fibroblast growth factor 4 Canis lupus familiaris Chr18 : 49090454 - 49093840 Homologene, Ensembl, NCBI gene
FGF19 fibroblast growth factor 19 Canis lupus familiaris Chr18 : 49142011 - 49147073 Homologene, Ensembl, NCBI gene
FGF3 fibroblast growth factor 3 Canis lupus familiaris Chr18 : 49057796 - 49065400 Homologene, Ensembl, NCBI gene
ORAOV1 oral cancer overexpressed 1 Canis lupus familiaris Chr18 : 49159378 - 49167844 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2015 Waldo,J.T.,Diaz,K.S.: :
Development and validation of a diagnostic test for Ridge allele copy number in Rhodesian Ridgeback dogs. Canine Genet Epidemiol 2:2, 2015.
Pubmed reference: 26401330 . DOI: 10.1186/s40575-015-0013-x .
2009 Andersson,L.: :
Genome-wide association analysis in domestic animals: a powerful approach for genetic dissection of trait loci. Genetica 136:341-9, 2009.
Pubmed reference: 18704695 . DOI: 10.1007/s10709-008-9312-4 .
2008 Rahal,S.,Mortari,AC.,Yamashita,S.,Filho,MM.,Hatschbac,E.,Sequeira,JL.: :
Magnetic resonance imaging in the diagnosis of type 1 dermoid sinus in two Rhodesian ridgeback dogs. Can Vet J 49:871-6, 2008.
Pubmed reference: 10713979 .
2007 Karlsson,E.K.,Baranowska,I.,Wade,C.M.,SalmonHillbertz,N.H.,Zody,M.C.,Anderson,N.,Biagi,T.M.,Patterson,N.,Pielberg,G.R.,Kulbokas,E.J.,Comstock,K.E.,Keller,E.T.,Mesirov,J.P.,vonEuler,H.,Kämpe,O.,Hedhammar,A.,Lander,E.S.,Andersson,G.,Andersson,L.,Lindblad-Toh,K.: :
Efficient mapping of mendelian traits in dogs through genome-wide association. Nat Genet 39:1321-8, 2007.
Pubmed reference: 17906626 . DOI: 10.1038/ng.2007.10 .
2007 SalmonHillbertz,N.H.,Isaksson,M.,Karlsson,E.K.,Hellmén,E.,Pielberg,G.R.,Savolainen,P.,Wade,C.M.,vonEuler,H.,Gustafson,U.,Hedhammar,A.,Nilsson,M.,Lindblad-Toh,K.,Andersson,L.,Andersson,G.: :
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs. Nat Genet 39:1318-20, 2007.
Pubmed reference: 17906623 . DOI: 10.1038/ng.2007.4 .
2006 Hillbertz,NH.,Andersson,G.: :
Autosomal dominant mutation causing the dorsal ridge predisposes for dermoid sinus in Rhodesian ridgeback dogs. J Small Anim Pract 47:184-8, 2006.
Pubmed reference: 16573760 . DOI: 10.1111/j.1748-5827.2006.00016.x .
2005 Hillbertz,NH.: :
Inheritance of dermoid sinus in the Rhodesian ridgeback. J Small Anim Pract 46:71-4, 2005.
Pubmed reference: 15736812 .
2000 Tshamala,M.,Moens,Y.: :
True dermoid cyst in a Rhodesian ridgeback Journal of Small Animal Practice 41:352-353, 2000.
Pubmed reference: 11002937 .
1999 Cornegliani,L.,Ghibaudo,G.: :
A dermoid sinus in a Siberian Husky Veterinary Dermatology 10:47-49, 1999.
1998 Booth,M.J.: :
Atypical dermoid sinus in a chow chow dog Journal of the South African Veterinary Medical Association 69:102-104, 1998.
1995 Fatone,G.,Brunetti,A.,Lamagna,F.,Potena,A.: :
Dermoid sinus and spinal malformations in a Yorkshire terrier: Diagnosis and follow-up Journal of Small Animal Practice 36:178-180, 1995.
Pubmed reference: 7603060 .
1993 Marks,S.L.,Harari,J.,Dernell,W.S.: :
Dermoid Sinus in a Rhodesian Ridgeback Journal of Small Animal Practice 34:356-358, 1993.
1992 Kása,F.,Kása,G.,Kussinger,S.: :
[Dermoid sinus in a Rhodesian ridgeback. Case report]. Tierarztl Prax 20:628-31, 1992.
Pubmed reference: 1481220 .
1989 Williams,ML.: :
The ridgeback anomaly. Arch Dermatol 125:1144, 1989.
Pubmed reference: 2642687 .
1986 Gammie,JS.: :
Dermoid sinus removal in a rhodesian ridgeback dog. Can Vet J 27:250-1, 1986.
Pubmed reference: 17422670 .
1979 Hathcock,JT.,Clampett,EG.,Broadstone,RV.: :
Dermoid sinus in a Rhodesian Ridgeback. Vet Med Small Anim Clin 74:53-6, 1979.
Pubmed reference: 256350 .
1970 Antin,IP.: :
Dermoid sinus in a Rhodesian Ridgeback dog. J Am Vet Med Assoc 157:961-2, 1970.
Pubmed reference: 4919487 .
1966 Mann,G.E.,Stratton,J.: :
Dermoid sinus in the Rhodesian Ridgeback Journal of Small Animal Practice 7:631-642, 1966.
Pubmed reference: 5951011 .
1957 Lord,L.H.,Cawley,A.J.,Gilray,J.: :
Mid dorsal dermoid sinuses in Rhodesian Ridgeback dogs - a case report Journal of the American Veterinary Medical Association 131:515-518, 1957.