Possible human homologues (MIM numbers):
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal Semi-Dominant
Considered a defect: yes
Year key mutation first reported: 2008
Species-specific name: Canine ectodermal dysplasia
Species-specific symbol: CED
More detail information can see in
iDog Breed Number | Breed Name | Personality | Height | Weight | History | Breed Source |
---|---|---|---|---|---|---|
CB72 | Chinese Crested | 27.9-33 cm | 3.6-5.4 kg | Africa, Mexico | ||
CB261 | Xoloitzcuintli(Mexican Hairless Dog) | 25.4-35.6 cm (toy), 35.6-45.7 cm (miniature), 45.7-58.4 cm (standard) | 4.5-6.8 kg (toy), 6.8-13.6 kg (miniature), 13.6-24.9 kg (standard) | Mexico | ||
CB181 | Peruvian Inca Orchid(Peruvian Hairless Dog) | Peru |
Symbol | Description | Species | Position | Other Links |
---|---|---|---|---|
FOXI3 | forkhead box I3 | Canis lupus familiaris | Chr17 : 38764819 - 38768812 | Homologene, Ensembl, NCBI gene |
2017 |
Kupczik,K.,Cagan,A.,Brauer,S.,Fischer,M.S.: :
The dental phenotype of hairless dogs with FOXI3 haploinsufficiency. Sci Rep 7:5459, 2017. Pubmed reference: 28710361 . DOI: 10.1038/s41598-017-05764-5 . |
2017 |
Parker,H.G.,Harris,A.,Dreger,D.L.,Davis,B.W.,Ostrander,E.A.: :
The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci 372:, 2017. Pubmed reference: 27994129 . DOI: 10.1098/rstb.2015.0488 . |
2013 |
Shirokova,V.,Jussila,M.,Hytönen,M.K.,Perälä,N.,Drögemüller,C.,Leeb,T.,Lohi,H.,Sainio,K.,Thesleff,I.,Mikkola,M.L.: :
Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes. Dev Dyn 242:593-603, 2013. Pubmed reference: 23441037 . DOI: 10.1002/dvdy.23952 . |
2013 |
Wiener,D.J.,Gurtner,C.,Panakova,L.,Mausberg,T.B.,Müller,E.J.,Drögemüller,C.,Leeb,T.,Welle,M.M.: :
Clinical and histological characterization of hair coat and glandular tissue of Chinese crested dogs. Vet Dermatol 24:274-e62, 2013. Pubmed reference: 23413772 . DOI: 10.1111/vde.12008 . |
2008 |
Drögemüller,C.,Karlsson,E.K.,Hytönen,M.K.,Perloski,M.,Dolf,G.,Sainio,K.,Lohi,H.,Lindblad-Toh,K.,Leeb,T.: :
A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science 321:1462, 2008. Pubmed reference: 18787161 . DOI: 10.1126/science.1162525 . |
2005 |
O'Brien,DP.,Johnson,GS.,Schnabel,RD.,Khan,S.,Coates,JR.,Johnson,GC.,Taylor,JF.: :
Genetic mapping of canine multiple system degeneration and ectodermal dysplasia loci. J Hered 96:727-34, 2005. Pubmed reference: 15958791 . DOI: 10.1093/jhered/esi086 . |
2005 |
Sander,P.,Drögemüller,C.,Cadieu,E.,André,C.,Leeb,T.: :
Analysis of the canine EDAR gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog. Anim Genet 36:168-71, 2005. Pubmed reference: 15771734 . DOI: 10.1111/j.1365-2052.2005.01242.x . |
1993 |
Kimura,T.,Ohshima,S.,Doi,K.: :
The Inheritance and Breeding Results of Hairless Descendants of Mexican Hairless Dogs Laboratory Animals 27:55-58, 1993. Pubmed reference: 8437436 . |
1985 |
Robinson,R.: :
Chinese crested dog Journal of Heredity 76:217-218, 1985. Pubmed reference: 3998444 . |