The detail information of Ectodermal dysplasia
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Semi-Dominant

Considered a defect: yes

Year key mutation first reported: 2008

Species-specific name: Canine ectodermal dysplasia

Species-specific symbol: CED

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB72 Chinese Crested 27.9-33 cm 3.6-5.4 kg Africa, Mexico
CB261 Xoloitzcuintli(Mexican Hairless Dog) 25.4-35.6 cm (toy), 35.6-45.7 cm (miniature), 45.7-58.4 cm (standard) 4.5-6.8 kg (toy), 6.8-13.6 kg (miniature), 13.6-24.9 kg (standard) Mexico
CB181 Peruvian Inca Orchid(Peruvian Hairless Dog) Peru
Associated Gene
Symbol Description Species Position Other Links
FOXI3 forkhead box I3 Canis lupus familiaris Chr17 : 38764819 - 38768812 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Kupczik,K.,Cagan,A.,Brauer,S.,Fischer,M.S.: :
The dental phenotype of hairless dogs with FOXI3 haploinsufficiency. Sci Rep 7:5459, 2017.
Pubmed reference: 28710361 . DOI: 10.1038/s41598-017-05764-5 .
2017 Parker,H.G.,Harris,A.,Dreger,D.L.,Davis,B.W.,Ostrander,E.A.: :
The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci 372:, 2017.
Pubmed reference: 27994129 . DOI: 10.1098/rstb.2015.0488 .
2013 Shirokova,V.,Jussila,M.,Hytönen,M.K.,Perälä,N.,Drögemüller,C.,Leeb,T.,Lohi,H.,Sainio,K.,Thesleff,I.,Mikkola,M.L.: :
Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes. Dev Dyn 242:593-603, 2013.
Pubmed reference: 23441037 . DOI: 10.1002/dvdy.23952 .
2013 Wiener,D.J.,Gurtner,C.,Panakova,L.,Mausberg,T.B.,Müller,E.J.,Drögemüller,C.,Leeb,T.,Welle,M.M.: :
Clinical and histological characterization of hair coat and glandular tissue of Chinese crested dogs. Vet Dermatol 24:274-e62, 2013.
Pubmed reference: 23413772 . DOI: 10.1111/vde.12008 .
2008 Drögemüller,C.,Karlsson,E.K.,Hytönen,M.K.,Perloski,M.,Dolf,G.,Sainio,K.,Lohi,H.,Lindblad-Toh,K.,Leeb,T.: :
A mutation in hairless dogs implicates FOXI3 in ectodermal development. Science 321:1462, 2008.
Pubmed reference: 18787161 . DOI: 10.1126/science.1162525 .
2005 O'Brien,DP.,Johnson,GS.,Schnabel,RD.,Khan,S.,Coates,JR.,Johnson,GC.,Taylor,JF.: :
Genetic mapping of canine multiple system degeneration and ectodermal dysplasia loci. J Hered 96:727-34, 2005.
Pubmed reference: 15958791 . DOI: 10.1093/jhered/esi086 .
2005 Sander,P.,Drögemüller,C.,Cadieu,E.,André,C.,Leeb,T.: :
Analysis of the canine EDAR gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog. Anim Genet 36:168-71, 2005.
Pubmed reference: 15771734 . DOI: 10.1111/j.1365-2052.2005.01242.x .
1993 Kimura,T.,Ohshima,S.,Doi,K.: :
The Inheritance and Breeding Results of Hairless Descendants of Mexican Hairless Dogs Laboratory Animals 27:55-58, 1993.
Pubmed reference: 8437436 .
1985 Robinson,R.: :
Chinese crested dog Journal of Heredity 76:217-218, 1985.
Pubmed reference: 3998444 .