The detail information of Lens luxation
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Year key mutation first reported: 2010

Species-specific name: Primary lens luxation; isolated canine ectopia lentis

Species-specific symbol: PPL

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
Symbol Description Species Position Other Links
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 Canis lupus familiaris Chr3 : 41014731 - 41340884 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Lewis,T.W.,Mellersh,C.S.: :
Changes in mutation frequency of eight Mendelian inherited disorders in eight pedigree dog populations following introduction of a commercial DNA test. PLoS One 14:e0209864, 2019.
Pubmed reference: 30650096 . DOI: 10.1371/journal.pone.0209864 .
2018 Oliver,J.A.C.,Rustidge,S.,Pettitt,L.,Jenkins,C.A.,Farias,F.H.G.,Giuliano,E.A.,Mellersh,C.S.: :
Evaluation of ADAMTS17 in Chinese Shar-Pei with primary open-angle glaucoma, primary lens luxation, or both. Am J Vet Res 79:98-106, 2018.
Pubmed reference: 29287154 . DOI: 10.2460/ajvr.79.1.98 .
2015 Gharahkhani,P.,O'Leary,C.A.,Duffy,D.L.,Kyaw-Tanner,M.: :
Potential Modifying Loci Associated With Primary Lens Luxation, Pedal Hyperkeratosis, and Ocular Phenotypes in Miniature Bull Terriers. Invest Ophthalmol Vis Sci 56:8288-96, 2015.
Pubmed reference: 26720482 . DOI: 10.1167/iovs.15-18074 .
2014 [Noauthorslisted]: :
[Lens luxation in dogs: a retrospective study of 134 dogs (2000-2011)]. Schweiz Arch Tierheilkd 156:125-31, 2014.
Pubmed reference: 24568806 . DOI: 10.1024/0036-7281/a000562 .
2014 Montgomery,K.W.,Labelle,A.L.,Gemensky-Metzler,A.J.: :
Trans-corneal reduction of anterior lens luxation in dogs with lens instability: a retrospective study of 19 dogs (2010-2013). Vet Ophthalmol :, 2014.
Pubmed reference: 24405506 . DOI: 10.1111/vop.12142 .
2013 Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013.
Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 .
2012 Gharahkhani,P.,O’Leary,C.,Duffy,D.,Bernays,M.,Kyaw-Tanner,M.: :
Primary Lens Luxation in Australian Tenterfield and Miniature Bull Terriers is due to an old ADAMTS17 Mutation and is an Additive Trait. Open Genomics Journal 5:7-13, 2012.
DOI: 10.2174/1875693X01205010007 .
2011 Gould,D.,Pettitt,L.,McLaughlin,B.,Holmes,N.,Forman,O.,Thomas,A.,Ahonen,S.,Lohi,H.,O'Leary,C.,Sargan,D.,Mellersh,C.: :
ADAMTS17 mutation associated with primary lens luxation is widespread among breeds. Vet Ophthalmol 14:378-384, 2011.
Pubmed reference: 22050825 . DOI: 10.1111/j.1463-5224.2011.00892.x .
2010 Farias,FH.,Johnson,GS.,Taylor,JF.,Giuliano,E.,Katz,ML.,Sanders,DN.,Schnabel,RD.,McKay,SD.,Khan,S.,Gharahkhani,P.,O'Leary,CA.,Pettitt,L.,Forman,OP.,Boursnell,M.,Mclaughlin,B.,Ahonen,S.,Lohi,H.,Hernandez-Merino,E.,Gould,DJ.,Sargan,D.,Mellersh,CS.: :
An ADAMTS17 Splice Donor Site Mutation in Dogs with Primary Lens Luxation. Invest Ophthalmol Vis Sci :, 2010.
Pubmed reference: 20375329 . DOI: 10.1167/iovs.09-5142 .
2009 Stuhr,CM.,Schilke,HK.,Forte,C.: :
Intracapsular lensectomy and sulcus intraocular lens fixation in dogs with primary lens luxation or subluxation. Vet Ophthalmol 12:357-60, 2009.
Pubmed reference: 19883465 . DOI: 10.1111/j.1463-5224.2009.00731.x .
2008 Oberbauer,AM.,Hollingsworth,SR.,Belanger,JM.,Regan,KR.,Famula,TR.: :
Inheritance of cataracts and primary lens luxation in Jack Russell Terriers. Am J Vet Res 69:222-7, 2008.
Pubmed reference: 18241019 . DOI: 10.2460/ajvr.69.2.222 .
2007 Sargan,DR.,Withers,D.,Pettitt,L.,Squire,M.,Gould,DJ.,Mellersh,CS.: :
Mapping the mutation causing lens luxation in several terrier breeds. J Hered 98:534-8, 2007.
Pubmed reference: 17573382 . DOI: 10.1093/jhered/esm029 .
2004 Ketteritzsch,K.,Hamann,H.,Brahm,R.,Grussendorf,H.,Rosenhagen,C.U.,Distl,O.: :
Genetic analysis of presumed inherited eye diseases in Tibetan Terriers. Vet J 168:151-9, 2004.
Pubmed reference: 15301763 . DOI: 10.1016/j.tvjl.2003.08.005 .
2004 Ketteritzsch,K.,Hamann,H.,Brahm,R.,Grussendorf,H.,Rosenhagen,CU.,Distl,O.: :
Genetic analysis of presumed inherited eye diseases in Tibetan Terriers. Vet J 168:151-9, 2004.
Pubmed reference: 15301758 . DOI: 10.1016/S1090-0233(03)00143-6 .
1998 Lazarus,JA.,Pickett,JP.,Champagne,ES.: :
Primary lens luxation in the Chinese Shar Pei: clinical and hereditary characteristics. Vet Ophthalmol 1:101-107, 1998.
Pubmed reference: 11397217 .
1990 Curtis,R.: :
Lens Luxation in the Dog and Cat Veterinary Clinics of North America-Small Animal Practice 20:755-773, 1990.
Pubmed reference: 2194357 .
1983 Curtis,R.: :
Aetiopathological aspects of inherited lens dislocation in the Tibetan Terrier. J Comp Pathol 93:151-63, 1983.
Pubmed reference: 6601667 .
1983 Curtis,R.,Barnett,KC.,Lewis,SJ.: :
Clinical and pathological observations concerning the aetiology of primary lens luxation in the dog. Vet Rec 112:238-46, 1983.
Pubmed reference: 6601878 .
1983 Curtis,R.,Barnett,KC.,Startup,FG.: :
Primary lens luxation in the miniature bull terrier. Vet Rec 112:328-30, 1983.
Pubmed reference: 6602414 .
1982 Curtis,R.: :
Hereditary luxation of the canine lens. Animal health trust small animals centre, newmarket. Trans Ophthalmol Soc U K 102 Pt 3:398-402, 1982.
Pubmed reference: 6985238 .
1980 Curtis,R.,Barnett,KC.: :
Primary lens luxation in the dog. J Small Anim Pract 21:657-68, 1980.
Pubmed reference: 6969820 .
1979 Willis,M.B.,Barnett,K.C.,Tempest,W.M.: :
Genetic aspects of lens luxation in the Tibetan Terrier Veterinary Record 104:409-412, 1979.
Pubmed reference: 314700 .
1978 Barnett,K.C.,Curtis,R.: :
Lens luxation and progressive retinal atrophy in the Tibetan Terrier Veterinary Record :160 only, 1978.
Pubmed reference: 308725 .
1971 Gelatt,K.N.: :
Glaucoma and lens luxation in a dog Veterinary Medicine and Small Animal Clinician 66:1102-1104, 1971.
Pubmed reference: 5209417 .
1970 Chandler,E.A.: :
Lens luxation in the Webster Terrier Veterinary Record 86:145-146, 1970.
Pubmed reference: 5461252 .
1969 Lawson,DD.: :
Luxation of the crystalline lens in the dog. J Small Anim Pract 10:461-3, 1969.
Pubmed reference: 5387868 .