Part1: Gene Information
The cancer module summarizes DNA methylation biomarkers with accurate genomic information via WGBS data to enhance the potential application of cancer DNA methylation research in clinical settings.
Search
Step1: Choose cancer type
Search cancer by name
Step 2: Choose gene
Search gene by ID
OR
Search gene by symbol
Result
Part2: DMRs with queried gene
| Gene ID | Gene symbol | Chromosome | Start position | End position | Length | Annotation | Distance to TSS | P-value | Differential methylation value | Cancer methylation level | Normal methylation level | Cancer type |
|---|
Part3: DMRs annotation summary
Number of related genomic regulatory elements with the selected DMRs
Detailed annotation results
Enhancer information
| Chromosome | Start position | End position | Length | Differential methylation value | Annotation | Gene Symbol | Enhancer position | Enhancer downstream gene | Enhancer tissue | Enhancer condition | Enhancer location | Enhancer type | Enhancer source |
|---|
Tips: we collected 9,447,227 enhancers from ENdb(430), EnhancerAtlas 2.0(7,272,472), SEA(2,174,325), FANTOM5, and VISTA database.
| Chromosome | Start position | End position | Length | Differential methylation value | Annotation | Gene Symbol | Super enhancer position | Super enhancer downstream gene | Super enhancer tissue | Super enhancer condition | Super enhancer location | Super enhancer pmid | Super enhancer type | Super enhancer source |
|---|
Tips: we collected 106,907 super enhancers from ENdb(50) and SEA(106,857) database.
| Chromosome | Start position | End position | Length | Differential methylation value | Annotation | Gene Symbol | Disease enhancer position | Disease enhancer downstream gene | Disease enhancer id | Disease enhancer condition | Disease enhancer location |
|---|
Tips: we collected 1,397 disease enhancers from diseaseEnhancer database.
| Chromosome | Start position | End position | Length | Differential methylation value | Annotation | Gene Symbol | Cancer enhancer position | Cancer enhancer downstream gene | Cancer enhancer condition | Cancer enhancer location |
|---|
Tips: we collected 168,269 cancer enhancers from CancerEND database.
| Chromosome | Start position | End position | Length | Differential methylation value | Annotation | Gene Symbol | Active enhancer position | Active enhancer downstream gene | Active enhancer tissue | Active enhancer cell | Active enhancer pmid | Active enhancer type |
|---|
Tips: we collected 1,549,063 active enhancers from HACER database.
Silencer information
| Chromosome | Start position | End position | Length | Differential methylation value | Annotation | Gene Symbol | Silencer position | Silencer ID | Silencer tissue | Silencer cell | Silencer location | Silencer type |
|---|
Tips: we collected 3,559,938 silencers from SilencerDB database.
Transcription factor information
| Chromosome | Start position | End position | Length | Differential methylation value | Annotation | Gene Symbol | Transcription factor position | Transcription factor ID | Transcription factor name | Transcription factor binding sequence logo | Transcription factor cell line | Transcription factor location |
|---|
Tips: we collected 182,416,820 transcriptional factors from ReMap2022 and JASPAR database.
Gene expression information