Effects of cromakalim, a potassium channel opener, on regional blood flow in conscious spontaneously hypertensive rats.

T Shoji, Y Aki, K Fukui, T Tamaki, H Iwao, Y Abe
Author Information
  1. T Shoji: Department of Pharmacology, Kagawa Medical School, Japan.

Abstract

We studied the effects of cromakalim, a potassium channel opener, on regional blood flow in conscious spontaneously hypertensive rats using microspheres. Cromakalim produced significant hypotension and increased blood flow in the stomach, skeletal muscle and skin. Calculated vascular resistances decreased in many organ vascular beds. Although nifedipine also showed a similar hemodynamic profile, differences were observed in the brain, gastrointestinal tract and skin.

MeSH Term

Animals
Benzopyrans
Blood Pressure
Cromakalim
Heart Rate
Hemodynamics
Humans
Hypertension
Infant, Newborn
Microspheres
Nifedipine
Pyrroles
Rats
Rats, Inbred SHR
Regional Blood Flow
Vascular Resistance

Chemicals

Benzopyrans
Pyrroles
Cromakalim
Nifedipine

Word Cloud

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