The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes.

D Escande, D Thuringer, S Leguern, I Cavero
Author Information
  1. D Escande: Laboratory of Cellular Electrophysiology, Rhône-Poulenc Santé, Gennevilliers, France.

Abstract

In cardiac myocytes, cromakalim (BRL 34915), a potassium channel opener, activates a time-independent K+ current exhibiting poor voltage-sensitivity. This effect of cromakalim is antagonized by low concentrations of glibenclamide, a specific blocker of ATP-dependent K+ channels in cardiac cells. Direct recording of the activity of K+ channels in inside-out membrane patches, confirmed that cromakalim is a potent activator of ATP-dependent K+ channels in cardiac myocytes.

MeSH Term

Adenosine Triphosphate
Animals
Benzopyrans
Cromakalim
Glyburide
Guinea Pigs
Ion Channels
Myocardium
Potassium
Pyrroles

Chemicals

Benzopyrans
Ion Channels
Pyrroles
Cromakalim
Adenosine Triphosphate
Potassium
Glyburide

Word Cloud

Created with Highcharts 10.0.0K+cardiaccromakalimchannelsmyocytesATP-dependentBRL34915potassiumchannelopeneractivatestime-independentcurrentexhibitingpoorvoltage-sensitivityeffectantagonizedlowconcentrationsglibenclamidespecificblockercellsDirectrecordingactivityinside-outmembranepatchesconfirmedpotentactivatorisolated

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