The article analyses the use of endoscopic selective drug denervation of the stomach (ESDDS) in 58 patients with reflux esophagitis. Complex appraisal of the efficacy of the treatment showed the result to be good and satisfactory in one month in 96.4% of cases and 6 month after ESDDS in 89.1% of cases; the respective values in the same terms after nonoperative treatment were 66.7% and 54.5%. The pathogenetic substantiation of the use of ESDDS is the arrest of the flow of pathological vegetative impulses due to its action, which promotes restoration of regulation of the main functions of the gastroesophageal system which become almost natural, and normalizes processes of autocleansing of the esophagus. The method may be recommended for treating active manifestations of reflux esophagitis and preventing recurrences, including cases of its combination with duodenal ulcer.
