Lectin-mediated bacterial adhesion to human tissue.

J Beuth, H L Ko, G Uhlenbruck, G Pulverer

Author Information

J Beuth: Institute of Hygiene, University of Cologne, FRG.

PMID: 3125051 DOI: 10.1007/BF02014258

In vitro experiments with frozen sections of human lung and kidney demonstrated that adhesion of Streptococcus pneumoniae Pn 629 Type 14 and Pseudomonas aeruginosa ATCC 27853 to human cells was mediated by bacterial lectins (adhesins) with N-acetyl-D-glucosamine/D-galactose or N-acetyl-neuraminic acid specificity. Blocking of the lectin binding sites on bacterial surfaces with competitive carbohydrates completely prevented the bacterial adherence, whereas non-specific carbohydrates (D-mannose, D-xylose) did not inhibit adherence.

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Acetylglucosamine

Adhesins, Bacterial

Bacterial Adhesion

Bacterial Proteins

Humans

Kidney

Lectins

Lung

Pseudomonas aeruginosa

Sialic Acids

Streptococcus pneumoniae

Adhesins, Bacterial

Bacterial Proteins

Lectins

Sialic Acids

adhesin, Pseudomonas

Acetylglucosamine

Journal Article

Glycosylated Lipopeptides-Synthesis and Evaluation of Antimicrobial Activity and Cytotoxicity.Specific association of lectin LecB with the surface of Pseudomonas aeruginosa: role of outer membrane protein OprF.The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder.High-Affinity Lectin Ligands Enable the Detection of Pathogenic Biofilms: Implications for Diagnostics and Therapy.

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