Estimation of platelet adhesiveness on whole blood and platelet-rich plasma.

S Shaw, G D Pegrum, S Wolff
Author Information

Abstract

Platelet adhesive tests were carried out in parallel on whole blood and platelet-rich plasma. A column of glass microspherules was used and adenosine diphosphate (ADP) was added to the platelet-rich plasma before passage through the column. Preliminary observations were made to show the effect of the containers and the anticoagulant used. The influence on platelets when stored at 4 degrees C and standing or mixing at room temperature was also assessed. The apparatus used to measure adhesiveness was designed to produce a constant rate of flow through a standard column of glass microspherules. Using both methods, adhesiveness was studied on 70 healthy blood donors. The result showed a significant correlation between the level of adhesiveness found with each technique.

References

  1. Annu Rev Med. 1966;17:275-90 [PMID: 5327395]
  2. Lancet. 1966 Jul 23;2(7456):182-4 [PMID: 4161159]
  3. J Clin Pathol. 1967 Jan;20(1):56-64 [PMID: 5297360]
  4. Ann Med Exp Biol Fenn. 1966;44(1):88-92 [PMID: 5958691]
  5. Lancet. 1967 Sep 9;2(7515):542-3 [PMID: 4166896]
  6. Thromb Diath Haemorrh. 1966 Jul 31;16(1):100-4 [PMID: 5989038]
  7. Lancet. 1968 Apr 13;1(7546):779-83 [PMID: 4171129]
  8. J Clin Pathol. 1967 Sep;20(5):706-7 [PMID: 5602979]
  9. J Clin Pathol. 1968 May;21(3):397-401 [PMID: 5699080]
  10. J Clin Pathol. 1968 Nov;21(6):695-7 [PMID: 4887526]
  11. Acta Med Scand. 1969 Jan-Feb;185(1-2):127-31 [PMID: 5805962]
  12. Lancet. 1958 May 10;1(7028):996-8 [PMID: 13540238]
  13. Lancet. 1965 Jan 9;1(7376):75-7 [PMID: 14234204]

MeSH Term

Adenine Nucleotides
Adult
Aged
Anticoagulants
Blood Cell Count
Blood Platelets
Blood Preservation
Citrates
Female
Humans
Male
Middle Aged
Plasma
Platelet Adhesiveness
Temperature
Time Factors

Chemicals

Adenine Nucleotides
Anticoagulants
Citrates

Word Cloud

Created with Highcharts 10.0.0adhesivenessbloodplatelet-richplasmacolumnusedwholeglassmicrospherulesPlateletadhesivetestscarriedparalleladenosinediphosphateADPaddedpassagePreliminaryobservationsmadeshoweffectcontainersanticoagulantinfluenceplateletsstored4degreesCstandingmixingroomtemperaturealsoassessedapparatusmeasuredesignedproduceconstantrateflowstandardUsingmethodsstudied70healthydonorsresultshowedsignificantcorrelationlevelfoundtechniqueEstimationplatelet

Similar Articles

Cited By (7)