Nutritional factors influencing the results of toxicology experiments in animals.

Y Hayashi, M Takahashi, T Kokubo
Author Information

Abstract

The purpose of this paper is to present experimental data illustrating the importance of a toxicopathological basis necessary for understanding the role of nutrition on drug toxicity. Nutritional status constitutes an important factor capable of modulating the results of animal experiments in toxicology. Therefore, it is necessary in any toxicity testing to consider the effects of nutrition on drug toxicity and, at the same time, the effect of drug toxicity on the nutritional state of animals.

MeSH Term

Animals
Cardiomyopathies
Chronic Disease
Dietary Proteins
Energy Intake
Female
Kidney Diseases
Male
Monocrotaline
Nutritional Physiological Phenomena
Pyrrolizidine Alkaloids
Rats
Rats, Inbred F344
Rats, Inbred Strains
Toxicology

Chemicals

Dietary Proteins
Pyrrolizidine Alkaloids
Monocrotaline

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