The relationship of toothbrushing to dental decay has remained unclear. In the present study an effort was made to throw more light on this problem. Clinical and interview data were obtained from 212 males. Potential confounding risk indicators were controlled by a multivariate confounder summarizing score. In general it was found that the values of caries prevalence indicator were consistently higher for sporadic toothbrushers. It was concluded that the current study provides evidence in favor of a positive association between toothbrushing and low caries prevalence.