A clinical evaluation of the effects of the antidepressive drug amitriptyline on the semen of 20 infertile men with oligoasthenozoospermia was carried out. Quantitative assessment of semen in the whole group showed significantly higher sperm counts, an increased proportion with normal sperm morphology and an increased semen volume after treatment, with a high positive correlation between sperm count before and after treatment. Individual qualitative evaluation showed an increased sperm count in 50% and increased motility in 35% of patients. It would seem that amitriptyline has a beneficial effect on semen in some of these patients.
