Protein structure prediction system based on artificial neural networks.

J Vanhala, K Kaski
Author Information
  1. J Vanhala: Tampere University of Technology/Microelectronics Laboratory, Finland.

Abstract

Methods based on the neural network techniques are among the most accurate in the secondary structure prediction of globular proteins. Here the same principles have been used for the tertiary structure prediction problem. The map of dihedral phi and psi angles is divided into 10 by 10 squares each spanning 36 by 36 degrees. By predicting the classification of each residue in the protein chain in this map a rough tertiary structure can be deduced. A complete prediction system running on a cluster of workstations and a graphical user interface was developed.

MeSH Term

Amino Acid Sequence
Animals
Aprotinin
Cattle
Forecasting
Humans
Models, Molecular
Molecular Sequence Data
Muramidase
Neural Networks, Computer
Pancreatic Polypeptide
Protein Structure, Tertiary
User-Computer Interface

Chemicals

pancreatic polypeptide, avian
Pancreatic Polypeptide
Aprotinin
Muramidase

Word Cloud

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