The incidence of drug resistant tuberculosis in 1279 Korean patients.

H Yum, Y Song, S Jeon, S Choi, B Lee, D Kim
Author Information
  1. H Yum: Department of Internal Medicine Paik Hospital, Inje University, Seoul, Korea.

Abstract

OBJECTIVES: In the past decade, the incidence of tuberculosis has been decreased in Korea and the nationwide survey of tuberculosis from 1965 through 1990 suggested a declining tendency of resistant organisms. But the prevalence rate of multidrug resistance of Mycobacterium tuberculosis is still a serious problem in Korea, and the aim of this study is to check the drug resistance pattern in the patients visiting University Hospital, the 3rd referral center.
METHODS: We reviewed 1279 cases (522 female, 757 male, mean age 39.4 +/- 16.7) of bacteriologically proven tuberculosis seen during the period from 1986 to 1992 retrospectively. Of 1093 patients, who were indentified in previous medical history, 454 (41.5%) had a history of prior antituberculous chemotherapy.
RESULTS: Resistance rate (resistant to 1 or more drugs) was 33.9%. Eleven percent of patients had resistance to a single drug (INH: 80.6%). Twenty two percent of patients had resistance to 2 or more drugs. Resistance rate is higher (47.4%) in the patients with a history of prior treatment than without a history (25.5%).
CONCLUSIONS: These data suggest that the high rate of multidrug resistance in Korea did not show any decreasing tendency. So, mycobacterial culture and sensitivity tests should be recommended at initial treatment of tuberculosis and potent antituberculosis drugs are strongly recommended.

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MeSH Term

Adult
Aged
Antitubercular Agents
Drug Resistance, Microbial
Female
Humans
Incidence
Korea
Male
Middle Aged
Mycobacterium tuberculosis
Prevalence
Tuberculosis
Tuberculosis, Multidrug-Resistant

Chemicals

Antitubercular Agents

Word Cloud

Created with Highcharts 10.0.0tuberculosispatientsresistanceratehistoryKorearesistantdrugdrugsincidencetendencymultidrug12795%priorResistancepercenttreatmentrecommendedOBJECTIVES:pastdecadedecreasednationwidesurvey19651990suggesteddecliningorganismsprevalenceMycobacteriumstillseriousproblemaimstudycheckpatternvisitingUniversityHospital3rdreferralcenterMETHODS:reviewedcases522female757malemeanage394+/-167bacteriologicallyprovenseenperiod19861992retrospectively1093indentifiedpreviousmedical45441antituberculouschemotherapyRESULTS:1339%ElevensingleINH:806%Twentytwo2higher474%without25CONCLUSIONS:datasuggesthighshowdecreasingmycobacterialculturesensitivitytestsinitialpotentantituberculosisstronglyKorean

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