- K T Weber: Department of Internal Medicine, University of Missouri Health Sciences Center, Columbia 65212, USA.
Over the past 25 years, a great deal has been learned about the pathophysiology and management of Heart failure--a major health problem whose prevalence and incidence have not declined, unlike other cardiovascular disorders. Several of these lessons are reviewed herein. However, despite these advances, important issues remain to challenge both the practicing physician and the research scientist.