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Proceedings of the National Academy of Sciences of the United States of America
Feb 14, 1995;92 (4): 1057-61.

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

W J Grossman, J T Kimata, F H Wong, M Zutter, T J Ley, L Ratner
Author Information
  1. W J Grossman: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.
PMID: 7862633 DOI: 10.1073/pnas.92.4.1057

Abstract

The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.

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MeSH Term

Animals
Base Sequence
Cell Compartmentation
DNA Probes
Genes, pX
Granzymes
Human T-lymphotropic virus 1
Humans
Leukemia, Experimental
Male
Mice
Mice, Transgenic
Molecular Sequence Data
Promoter Regions, Genetic
Serine Endopeptidases
T-Lymphocytes

Chemicals

DNA Probes
GZMB protein, human
Granzymes
Gzmb protein, mouse
Serine Endopeptidases
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Article has an altmetric score of 3

Word Cloud

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