DNA methylation, genomic imprinting, and mammalian development. - National Genomics Data Center (CNCB-NGDC)

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DNA methylation, genomic imprinting, and mammalian development.

E Li, C Beard, A C Forster, T H Bestor, R Jaenisch

Author Information

E Li: Massachusetts General Hospital-East, Cardiovascular Research Center, Charlestown 02129.

PMID: 7956042 DOI: 10.1101/sqb.1993.058.01.035

No abstract text available.

CA-60610/NCI NIH HHS
GM-00616/NIGMS NIH HHS
GM-43565/NIGMS NIH HHS

Alleles

Animals

Cell Line

DNA

DNA-Cytosine Methylases

Embryonic and Fetal Development

Gene Expression Regulation, Developmental

Genomic Imprinting

Homozygote

Insulin-Like Growth Factor II

Methylation

Mice

Mice, Mutant Strains

Mutation

RNA Precursors

RNA Splicing

Receptor, IGF Type 2

RNA Precursors

Receptor, IGF Type 2

Insulin-Like Growth Factor II

DNA

DNA-Cytosine Methylases

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

DNA methylation and genomic imprinting.Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting.Genomic imprinting and mammalian development.[Genomic imprinting and mammalian development].DNA methylation in genomic imprinting.DNA methylation in genomic imprinting, development, and disease.Genomic imprinting, DNA methylation, and cancer.DNA methylation and genomic imprinting in mammals.Genomic imprinting, DNA methylation, and cancer.Trophoblastic disease, genomic imprinting and DNA methylation.

DNA methylation specifies chromosomal localization of MeCP2.MethTools--a toolbox to visualize and analyze DNA methylation data.Dnmt1/Transcription factor interactions: an alternative mechanism of DNA methylation inheritance.Inheritance of an epigenetic mark: the CpG DNA methyltransferase 1 is required for de novo establishment of a complex pattern of non-CpG methylation.DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.Cytosine methylation and the unequal developmental potentials of the oocyte and sperm genomes.The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome.ESR1 gene promoter region methylation in free circulating DNA and its correlation with estrogen receptor protein expression in tumor tissue in breast cancer patients.Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.Silencing of metallothionein-I gene in mouse lymphosarcoma cells by methylation.

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