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Proceedings of the National Academy of Sciences of the United States of America
Jul 01, 1993;90 (13): 5974-8.

Thalidomide inhibits the replication of human immunodeficiency virus type 1.

S Makonkawkeyoon, R N Limson-Pobre, A L Moreira, V Schauf, G Kaplan
Author Information
  1. S Makonkawkeyoon: Rockefeller University, New York, NY 10021.
PMID: 8327469 DOI: 10.1073/pnas.90.13.5974

Abstract

Thalidomide, a selective inhibitor of tumor necrosis factor alpha (TNF-alpha) synthesis, suppresses the activation of latent human immunodeficiency virus type 1 (HIV-1) in a monocytoid (U1) line. The inhibition is dose dependent and occurs after exposure of the cells to recombinant TNF-alpha, phorbol myristate acetate, lipopolysaccharide, and other cytokine combinations. Associated with HIV-1 inhibition is a reduction in agonist-induced TNF-alpha protein and mRNA production. Thalidomide inhibition of virus replication in the phorbol myristate acetate- and recombinant TNF-alpha-stimulated T-cell line ACH-2 is not observed. The presence of thalidomide also inhibits the activation of virus in the peripheral blood mononuclear cells of 16 out of 17 patients with advanced HIV-1 infection and AIDS. These results suggest the use of thalidomide in a clinical setting to inhibit both virus replication and the TNF-alpha-induced systemic toxicity of HIV-1 and opportunistic infections.

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Grants

  1. AI-22616/NIAID NIH HHS
  2. AI-24775/NIAID NIH HHS

MeSH Term

Acquired Immunodeficiency Syndrome
Adult
Cell Line
Female
HIV Infections
HIV-1
Humans
Leukocytes, Mononuclear
Male
Middle Aged
Monocytes
RNA, Messenger
T-Lymphocytes
Thalidomide
Tumor Necrosis Factor-alpha
Virus Activation
Virus Replication

Chemicals

RNA, Messenger
Tumor Necrosis Factor-alpha
Thalidomide
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Article has an altmetric score of 3

Word Cloud

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