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Infection and immunity
Sep, 1996;64 (9): 3752-7.

Binding of resting platelets to Candida albicans germ tubes.

R Robert, C Mahaza, M Miegeville, J Ponton, A Marot-Leblond, J M Senet
Author Information
  1. R Robert: Laboratoire d'Immunologie-Mycologie-Bactériologie, UFR des Sciences Médicales et Pharmaceutiques, Angers, France.
PMID: 8751925 DOI: 10.1128/iai.64.9.3752-3757.1996

Abstract

The binding of resting platelets to Candida albicans germ tubes was studied by means of an affinity column in which germ tubes were physically immobilized. Adhesion of platelets to the column was dependent on both the germ tube concentration and the number of platelets applied. It was found that the interaction of C. albicans germ tubes with platelets is specific and should be mediated by a fungal protein receptor. The results obtained by scanning electron microscopy confirmed that resting platelets can fix directly onto germ tubes. In addition, this study showed that attachment of platelets onto C. albicans is associated with morphological changes. Platelets lost their discoid shape, became globular, generated spikes or pseudopods, and then flattened on the yeast cells.

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MeSH Term

Blood Platelets
Candida albicans
Chromatography, Affinity
Humans
Microscopy, Electron, Scanning
Platelet Adhesiveness
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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