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Emerging infectious diseases
1996 Jul-Sep;2 (3): 168-75.

DNA vaccines for emerging infectious diseases: what if?

R G Whalen
Author Information
  1. R G Whalen: Centre National de la Recherche Scientifique, Paris, France. whalen@pasteur.fr
PMID: 8903226 DOI: 10.3201/eid0203.960302

Abstract

A novel and powerful method for vaccine research, colloquially known as DNA vaccines, involves the deliberate introduction into tissues of a DNA plasmid carrying an antigen-coding gene that transfects cells in vivo and results in an immune response. DNA vaccines have several distinct advantages, which include ease of manipulation, use of a generic technology, simplicity of manufacture, and chemical and biological stability. In addition, DNA vaccines are a great leveler among re-searchers around the world because they provide unprecedented ease of experi-mentation. To facilitate diffusion of information, an Internet site has been established called THE DNA VACCINE WEB (URL:http://www.genweb.com/dnavax/dnavax.html). In this review, a brief survey is undertaken of the experimental models and preclinical work on DNA vaccines to contribute to a greater awareness of the possibilities for emerging infectious diseases.

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MeSH Term

Animals
Communicable Disease Control
Communicable Diseases
Disease Models, Animal
Humans
Research
Vaccines, DNA

Chemicals

Vaccines, DNA
Journal Article Review
Article has an altmetric score of 36

Word Cloud

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