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Molecular and cellular biochemistry
Jun, 1999;196 (1-2): 3-12.

Myocardial preconditioning: basic concepts and potential mechanisms.

S Okubo, L Xi, N L Bernardo, K Yoshida, R C Kukreja
Author Information
  1. S Okubo: Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
PMID: 10448897

Abstract

Preconditioning is a phenomenon, where brief periods of stress such as ischemia, heat shock or certain pharmacological agents make the heart tolerant to subsequent lethal ischemic injury. Preconditioning seems to involve a variety of stress signals which include activation of membrane receptors and signaling molecules such as protein kinase C, mitogen-activated protein kinases, opening of ATP-sensitive potassium channel and expression of a number of protective proteins. In this review, the potential role of these mechanisms is discussed.

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MeSH Term

Animals
Humans
Ischemic Preconditioning, Myocardial
Models, Cardiovascular
Journal Article Review

Word Cloud

Created with Highcharts 10.0.0PreconditioningstressproteinpotentialmechanismsphenomenonbriefperiodsischemiaheatshockcertainpharmacologicalagentsmakehearttolerantsubsequentlethalischemicinjuryseemsinvolvevarietysignalsincludeactivationmembranereceptorssignalingmoleculeskinaseCmitogen-activatedkinasesopeningATP-sensitivepotassiumchannelexpressionnumberprotectiveproteinsreviewrolediscussedMyocardialpreconditioning:basicconcepts

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