Miriamin, a defensive diterpene from the eggs of a land slug (Arion sp.).

F C Schroeder, A Gonzàlez, T Eisner, J Meinwald
Author Information
  1. F C Schroeder: Baker Laboratory, Department of Chemistry, Cornell University, Ithaca, NY 14853, USA.

Abstract

The eggs of the land slug Arion sp. contain a diterpene, miriamin, characterized as a polyoxygenated geranylgeraniol derivative. In bioassays with a coccinellid beetle, Harmonia axyridis, miriamin was shown to be potently antifeedant, indicating that the compound plays a protective role in nature. It is suggested that mucilaginous soil-inhabiting organisms, given their intense exposure to pathogens and predators, may be a rich source of chemical defensive agents.

References

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  2. J Med Chem. 1992 Apr 17;35(8):1458-65 [PMID: 1315394]
  3. Oecologia. 1993 Oct;96(1):9-18 [PMID: 28313747]
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Grants

  1. R01 GM053830/NIGMS NIH HHS
  2. AI02908/NIAID NIH HHS
  3. GM53830/NIGMS NIH HHS

MeSH Term

Animals
Biological Assay
Coleoptera
Diterpenes
Feeding Behavior
Female
Molecular Structure
Mollusca
Ovum

Chemicals

Diterpenes
miriamin

Word Cloud

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