Negative control of flagellum synthesis in Pseudomonas aeruginosa is modulated by the alternative sigma factor AlgT (AlgU).
E S Garrett, D Perlegas, D J Wozniak
Author Information
E S Garrett: Department of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Many respiratory isolates of Pseudomonas aeruginosa from cystic fibrosis patients are mucoid (alginate producing) yet lack flagella. It was hypothesized that an alginate regulator inhibits flagellar gene expression. Mutations in algB, algR, and algT resulted in nonmucoid derivatives, yet algT mutants expressed flagella. AlgT-dependent control of flagellum synthesis occurred through inhibition of fliC but not rpoN transcription.
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P30 CA012197/NCI NIH HHS
R01 HL058334/NHLBI NIH HHS
5R01 HL58334/NHLBI NIH HHS
CA-12197/NCI NIH HHS
Alginates
Bacterial Proteins
Carbohydrate Dehydrogenases
Catechol 2,3-Dioxygenase
DNA-Binding Proteins
Dioxygenases
Flagella
Flagellin
Gene Expression Regulation, Bacterial
Microscopy, Electron
Movement
Mutation
Oxygenases
Phenotype
Pseudomonas aeruginosa
Sigma Factor
Trans-Activators
Transcription Factors
Transcription, Genetic
AlgR protein, Pseudomonas aeruginosa
AlgU protein, Pseudomonas aeruginosa
Alginates
Bacterial Proteins
DNA-Binding Proteins
Sigma Factor
Trans-Activators
Transcription Factors
Flagellin
AlgB protein, Pseudomonas
Carbohydrate Dehydrogenases
GDPmannose dehydrogenase
Oxygenases
Dioxygenases
Catechol 2,3-Dioxygenase
