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Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
2001 Jan-Feb;8 (1): 89-97.

Functional, structural, and genetic mitochondrial abnormalities in myocardial diseases.

A Brega, J Narula, E Arbustini
Author Information
  1. A Brega: Department of Biology and Genetics for Medical Sciences, University of Milan, Italy.
PMID: 11182713 DOI: 10.1067/mnc.2001.112755

Abstract

Myocardial tissue is highly dependent on energy supplied by normal mitochondrial function. Therefore defects of energy production or utilization affect the heart in both syndromic and isolated disorders. Knowledge of the peculiar structural, functional, and genetic characteristics of mitochondria provides the basis for identification and classification of mitochondrial defects as well as for establishment of a diagnostic workup useful for related cardiac disorders. This review is therefore dedicated to the characteristics of normal mitochondria and the pathologic alterations of these organelles in various cardiovascular diseases.

References

  1. Am J Pathol. 1998 Nov;153(5):1501-10 [PMID: 9811342]
  2. Nature. 1981 Apr 9;290(5806):457-65 [PMID: 7219534]
  3. Science. 1999 Mar 5;283(5407):1482-8 [PMID: 10066162]
  4. Pediatr Res. 1996 Mar;39(3):513-21 [PMID: 8929874]
  5. Lancet. 1991 Jul 20;338(8760):143-7 [PMID: 1677065]
  6. J Med Genet. 1997 Jul;34(7):607-9 [PMID: 9222976]
  7. Nucleic Acids Res. 1998 Jan 1;26(1):112-5 [PMID: 9399813]
  8. J Med Genet. 1999 Jul;36(7):542-5 [PMID: 10424815]
  9. Am J Hum Genet. 1999 May;64(5):1276-81 [PMID: 10205257]
  10. Biochem Soc Trans. 1990 Aug;18(4):509-13 [PMID: 2276421]
  11. Can J Appl Physiol. 1994 Mar;19(1):12-48 [PMID: 7832830]
  12. Nat Genet. 1997 Jul;16(3):226-34 [PMID: 9207786]
  13. Heart. 1998 Dec;80(6):548-58 [PMID: 10065021]
  14. Pediatr Cardiol. 1998 May-Jun;19(3):266-8 [PMID: 9568229]
  15. Circulation. 1995 Feb 15;91(4):955-61 [PMID: 7850981]
  16. J Inherit Metab Dis. 1992;15(4):487-98 [PMID: 1528009]
  17. Science. 1999 Mar 5;283(5407):1476-81 [PMID: 10066161]
  18. Biochimie. 1992 Feb;74(2):123-30 [PMID: 1581387]
  19. Science. 1988 Dec 9;242(4884):1427-30 [PMID: 3201231]
  20. Mol Cell Biol. 1981 Jun;1(6):497-511 [PMID: 6086013]
  21. Annu Rev Biochem. 1997;66:409-35 [PMID: 9242913]
  22. J Mol Cell Cardiol. 1997 Oct;29(10):2699-709 [PMID: 9344764]
  23. Am Heart J. 1992 Nov;124(5):1263-9 [PMID: 1442494]
  24. Genetics. 1992 Jan;130(1):163-73 [PMID: 1732158]
  25. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6715-9 [PMID: 6256757]
  26. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8144-9 [PMID: 10393962]
  27. Neuromuscul Disord. 1995 Sep;5(5):391-8 [PMID: 7496173]
  28. Cell. 1990 Jun 15;61(6):931-7 [PMID: 2112427]
  29. Gene. 1999 Sep 30;238(1):211-30 [PMID: 10570998]
  30. Proc Natl Acad Sci U S A. 1979 Apr;76(4):1967-71 [PMID: 109836]
  31. Eur Heart J. 2001 Jan;22(1):73-81 [PMID: 11133212]
  32. Am J Hum Genet. 1990 Apr;46(4):828-42 [PMID: 2316527]
  33. Jpn Heart J. 1962 Nov;3:537-43 [PMID: 13990927]
  34. J Mol Cell Cardiol. 1992 Jul;24(7):669-81 [PMID: 1404407]
  35. Prenat Diagn. 1999 Dec;19(12):1165-8 [PMID: 10590437]
  36. Am Heart J. 1991 Jun;121(6 Pt 1):1735-42 [PMID: 2035386]
  37. J Neurol Sci. 1997 Jul;149(1):111-7 [PMID: 9168175]
  38. Genomics. 1993 Jul;17(1):171-84 [PMID: 8104867]
  39. Bioessays. 1998 Feb;20(2):126-36 [PMID: 9631658]
  40. N Engl J Med. 1992 Jul 2;327(1):19-23 [PMID: 1598097]
  41. Hum Mutat. 1996;8(3):216-22 [PMID: 8889580]
  42. Eur Heart J. 1992 Oct;13(10 ):1393-8 [PMID: 1396814]
  43. Genetics. 1984 Mar;106(3):479-99 [PMID: 6323246]
  44. Nature. 1981 Apr 9;290(5806):470-4 [PMID: 7219536]

MeSH Term

Cardiomyopathies
Humans
Mitochondria, Heart
Mitochondrial Myopathies
Ultrasonography
Journal Article Research Support, Non-U.S. Gov't Review

Word Cloud

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