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Mar, 2001;23 (3): 251-60.

Ectopeptidases in pathophysiology.

C Antczak, I De Meester, B Bauvois
Author Information
  1. C Antczak: Institut Curie, INSERM 365, Paris, France.
PMID: 11223882 DOI: 10.1002/1521-1878(200103)23:3<251::AID-BIES1035>3.0.CO;2-O

Abstract

Ectopeptidases are transmembrane proteins present in a wide variety of tissues and cell types. Dysregulated expression of certain ectopeptidases in human malignancies suggests their value as clinical markers. Ectopeptidase interaction with agonistic antibodies or their inhibitors has revealed that these ectoenzymes are able to modulate bioactive peptide responses and to influence growth, apoptosis and differentiation, as well as adhesion and motility, all functions involved in normal and tumoral processes. There is evidence that ectopeptidase-mediated signal transduction frequently involves tyrosine phosphorylation. Combined analyses of gene organization and regulation of ectopeptidases by various physiological factors have provided insights into their structure-function relationships. Understanding the roles of ectopeptidases in pathophysiology may have implications in considering them as therapeutic targets.

References

  1. FASEB J. 1999 Jan;13(1):69-79 [PMID: 9872931]
  2. Cell Growth Differ. 1995 Sep;6(9):1163-70 [PMID: 8519693]
  3. Blood. 1993 Aug 15;82(4):1052-70 [PMID: 8102558]
  4. Immunol Rev. 1998 Feb;161:71-7 [PMID: 9553765]
  5. Immunol Lett. 1998 May;62(1):25-31 [PMID: 9672144]
  6. Adv Drug Deliv Rev. 1998 Apr 6;31(1-2):89-104 [PMID: 10837619]
  7. Mol Cell Biochem. 1981 Sep 25;39:357-68 [PMID: 6118826]
  8. Immunology. 1997 May;91(1):151-8 [PMID: 9203979]
  9. Leuk Res. 1996 Apr;20(4):357-63 [PMID: 8642848]
  10. Biochem J. 1994 Feb 1;297 ( Pt 3):503-8 [PMID: 7906515]
  11. Hum Pathol. 1994 Dec;25(12):1360-5 [PMID: 8001932]
  12. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8439-44 [PMID: 10900005]
  13. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7923-6 [PMID: 8755578]
  14. J Leukoc Biol. 2000 Mar;67(3):285-311 [PMID: 10733089]
  15. Eur J Immunol. 2000 Jul;30(7):1902-10 [PMID: 10940879]
  16. Eur J Clin Invest. 1997 Sep;27(9):788-90 [PMID: 9352252]
  17. Blood. 1999 Nov 1;94(9):3067-76 [PMID: 10556191]
  18. Blood. 2000 Jan 15;95(2):453-60 [PMID: 10627449]
  19. Cancer Res. 1991 Feb 15;51(4):1202-9 [PMID: 1997162]
  20. Curr Opin Cell Biol. 1997 Apr;9(2):180-6 [PMID: 9069255]
  21. Immunol Rev. 1998 Feb;161:119-27 [PMID: 9553769]
  22. J Rheumatol. 1996 Dec;23(12):2022-6 [PMID: 8970035]
  23. Hepatology. 1998 Apr;27(4):934-42 [PMID: 9537431]
  24. Transplantation. 1999 Jul 15;68(1):62-6 [PMID: 10428268]
  25. Immunol Today. 1999 Jun;20(6):278-84 [PMID: 10354553]
  26. Int J Mol Med. 1999 Jul;4(1):3-15 [PMID: 10373631]
  27. Biochem J. 1995 Nov 1;311 ( Pt 3):835-43 [PMID: 7487939]
  28. J Clin Oncol. 1998 Nov;16(11):3691-710 [PMID: 9817291]
  29. Immunol Lett. 2000 Feb 1;71(2):127-9 [PMID: 10714440]
  30. Br J Haematol. 1978 Apr;38(4):453-61 [PMID: 25665]
  31. Biochem J. 1997 Jan 15;321 ( Pt 2):265-79 [PMID: 9020855]
  32. Leukemia. 1999 May;13(5):729-34 [PMID: 10374877]
  33. Immunol Today. 1999 Aug;20(8):367-75 [PMID: 10431157]
  34. Immunobiology. 1993 Jan;187(1-2):24-35 [PMID: 8099341]
  35. Eur J Immunol. 1998 Dec;28(12):4123-9 [PMID: 9862348]
  36. Int J Mol Med. 1999 Jul;4(1):17-27 [PMID: 10373632]
  37. J Exp Med. 1995 Jun 1;181(6):2271-5 [PMID: 7760013]
  38. Immunol Lett. 1998 Mar;61(1):7-13 [PMID: 9580431]
  39. Mol Cell Biol. 2000 Feb;20(3):1089-94 [PMID: 10629066]
  40. Cytokine. 1995 Aug;7(6):526-33 [PMID: 8580368]
  41. Biochem J. 1999 Feb 15;338 ( Pt 1):91-7 [PMID: 9931303]
  42. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2552-7 [PMID: 9482924]
  43. Hum Genet. 1993 Mar;91(1):31-6 [PMID: 8095916]
  44. Am J Hematol. 1986 Mar;21(3):289-98 [PMID: 2868654]
  45. Mod Pathol. 1998 Sep;11(9):855-63 [PMID: 9758365]
  46. J Exp Med. 1999 Aug 2;190(3):311-22 [PMID: 10430620]
  47. Immunology. 1993 Nov;80(3):465-70 [PMID: 7904591]
  48. Semin Cancer Biol. 1996 Jun;7(3):111-8 [PMID: 8773296]
  49. Biochim Biophys Acta. 1997 Jul 10;1361(1):11-9 [PMID: 9247085]
  50. Biomed Pharmacother. 1998;52(9):397-402 [PMID: 9856287]
  51. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6874-9 [PMID: 10823914]
  52. Oncogene. 2000 Jan 13;19(2):265-72 [PMID: 10645005]
  53. Immunol Today. 1999 Feb;20(2):83-8 [PMID: 10098327]
  54. Nephrologie. 1998;19(7):391-5 [PMID: 9857373]
  55. J Biol Chem. 1997 Mar 21;272(12):7595-601 [PMID: 9065413]
  56. N Engl J Med. 1985 May 30;312(22):1405-11 [PMID: 2985995]
  57. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11653-8 [PMID: 10500232]
  58. Immunol Rev. 1998 Feb;161:43-53 [PMID: 9553763]
  59. Biomed Pharmacother. 1991;45(2-3):81-6 [PMID: 1717027]
  60. Circ Res. 2000 Feb 4;86(2):139-43 [PMID: 10666408]
  61. Blood. 1989 Oct;74(5):1728-37 [PMID: 2790198]
  62. Int Immunol. 1999 Nov;11(11):1791-800 [PMID: 10545483]
  63. J Immunol. 1995 Apr 1;154(7):3062-77 [PMID: 7534786]
  64. Cancer Res. 1997 Jul 15;57(14):2884-7 [PMID: 9230195]
  65. Int J Cancer. 1995 Aug 9;62(4):443-8 [PMID: 7635570]

MeSH Term

Cell Transformation, Neoplastic
Chromosome Mapping
Chromosomes, Human
Exopeptidases
Hematologic Neoplasms
Humans
Immune System Diseases
Neoplasms
Signal Transduction

Chemicals

Exopeptidases
Journal Article Research Support, Non-U.S. Gov't Review

Word Cloud

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