- Karen C Vermeulen: Division of Physics and Astronomy, Faculty of Sciences, Vrije Universiteit Amsterdam, The Netherlands.
Both experimental evidence and theoretical models for collective effects in the working mechanism of molecular motors are reviewed at three different levels, namely: (i) interaction between the two heads of double-headed motors, particularly in processive motors like kinesin, myosin V and myosin VI, (ii) cooperative regulation of muscle thin filaments by accessory proteins and the Ca2+ level, and (iii) collective dynamic effects stemming from the mechanical coupling of molecular motors within macroscopic structures such as muscle thick filaments or axonemes. We aim to bridge the gap between structural information at the molecular level and physiological data with accompanying specific models on the one hand, and general stochastic physical models for the action of molecular motors on the other hand. An underlying assumption is that while, ultimately, the function of molecular motors will be explainable by a quantitative description of specific intramolecular dynamics and intermolecular interactions, for some coarse grained larger scale dynamic features it will be sufficient and illuminating to construct physical models that are simplified to the bare essentials.