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2002;3 (12): RESEARCH0082.

Apollo: a sequence annotation editor.

S E Lewis, S M J Searle, N Harris, M Gibson, V Lyer, J Richter, C Wiel, L Bayraktaroglu, E Birney, M A Crosby, J S Kaminker, B B Matthews, S E Prochnik, C D Smithy, J L Tupy, G M Rubin, S Misra, C J Mungall, M E Clamp
Author Information
  1. S E Lewis: Department of Molecular and Cellular Biology, Life Sciences Addition, University of California, Berkeley, CA 94720-3200, USA. suzi@fruitfly.org
PMID: 12537571 DOI: 10.1186/gb-2002-3-12-research0082

Abstract

The well-established inaccuracy of purely computational methods for annotating genome sequences necessitates an interactive tool to allow biological experts to refine these approximations by viewing and independently evaluating the data supporting each annotation. Apollo was developed to meet this need, enabling curators to inspect genome annotations closely and edit them. FlyBase biologists successfully used Apollo to annotate the Drosophila melanogaster genome and it is increasingly being used as a starting point for the development of customized annotation editing tools for other genome projects.

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Grants

  1. P41 HG000739/NHGRI NIH HHS
  2. U41 HG000739/NHGRI NIH HHS
  3. HG00739/NHGRI NIH HHS
  4. HG00750/NHGRI NIH HHS

MeSH Term

Animals
Database Management Systems
Databases, Nucleic Acid
Humans
Software Design
User-Computer Interface
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review
Article has an altmetric score of 11

Word Cloud

Created with Highcharts 10.0.0genomeannotationApollousedwell-establishedinaccuracypurelycomputationalmethodsannotatingsequencesnecessitatesinteractivetoolallowbiologicalexpertsrefineapproximationsviewingindependentlyevaluatingdatasupportingdevelopedmeetneedenablingcuratorsinspectannotationscloselyeditFlyBasebiologistssuccessfullyannotateDrosophilamelanogasterincreasinglystartingpointdevelopmentcustomizededitingtoolsprojectsApollo:sequenceeditor

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