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Infection and immunity
Mar, 2003;71 (3): 1584-6.

Expression of variant surface antigens by Plasmodium falciparum parasites in the peripheral blood of clinically immune pregnant women indicates ongoing placental infection.

Michael F Ofori, Trine Staalsoe, Victoria Bam, Maja Lundquist, Kim P David, Edmund N L Browne, Bartholomew D Akanmori, Lars Hviid
Author Information
  1. Michael F Ofori: Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
PMID: 12595482 DOI: 10.1128/IAI.71.3.1584-1586.2003

Abstract

Placenta-sequestered Plasmodium falciparum parasites that cause pregnancy-associated malaria (PAM) in otherwise clinically immune women express distinct variant surface antigens (VSA(PAM)) not expressed by parasites in nonpregnant individuals. We report here that parasites from the peripheral blood of clinically immune pregnant women also express VSA(PAM), making them a convenient source of VSA(PAM) expressors for PAM vaccine research.

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MeSH Term

Animals
Antibodies, Protozoan
Antigens, Protozoan
Antigens, Surface
Female
Humans
Immunoglobulin G
Malaria, Falciparum
Placenta
Plasmodium falciparum
Pregnancy
Pregnancy Complications, Parasitic

Chemicals

Antibodies, Protozoan
Antigens, Protozoan
Antigens, Surface
Immunoglobulin G
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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