Genetic mapping of variation in spatial learning in the mouse.
Daniela Steinberger, David S Reynolds, Pushpindar Ferris, Rachael Lincoln, Susmita Datta, Joanna Stanley, Andrea Paterson, Gerard R Dawson, Jonathan Flint
Author Information
Daniela Steinberger: Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, United Kingdom.
Inbred strains of mice are known to differ in their performance in the Morris water maze task, a test of spatial discrimination and place navigation in rodents, but the genetic basis of individual variation in spatial learning is unknown. We have mapped genetic effects that contribute to the difference between two strains, DBA/2 and C57BL6/J, using an F2 intercross and methods to detect quantitative trait loci (QTL). We found two QTL, one on chromosome 4 and one on chromosome 12, that influence behavior in the probe trial of the water maze (genome-wide significance p = 0.017 and 0.015, respectively). By including tests of avoidance conditioning and behavior in a novel environment, we show that the QTL on chromosomes 4 and 12 specifically influence variation in spatial learning. QTL that influence differences in fearful behavior (on chromosomes 1, 3, 7, 15, and 19) operate while mice are trained in the water maze apparatus.
