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Proceedings of the National Academy of Sciences of the United States of America
Sep 16, 2003;100 (19): 11070-5.

Reward-dependent plasticity in the primary auditory cortex of adult monkeys trained to discriminate temporally modulated signals.

Ralph E Beitel, Christoph E Schreiner, Steven W Cheung, Xiaoqin Wang, Michael M Merzenich
Author Information
  1. Ralph E Beitel: Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA. beitel@phy.ucsf.edu
PMID: 12941865 DOI: 10.1073/pnas.1334187100

Abstract

Adult owl monkeys were trained to detect an increase in the envelope frequency of a sinusoidally modulated 1-kHz tone. Detection was positively correlated with the magnitude of the change in the envelope frequency. Surprisingly, neuronal responses recorded in the primary auditory cortex of trained monkeys were globally suppressed by the modulated tone. However, the contrast in neuronal responsiveness to small increases versus large increases in envelope frequencies was actually enhanced in the trained animals. The results suggest behaviorally contingent inhibitory and excitatory processes that are modulated by the probability that a particular signal predicts a reward.

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Grants

  1. P01 NS034835/NINDS NIH HHS
  2. R01 DC002260-08/NIDCD NIH HHS
  3. R01 NS010414/NINDS NIH HHS
  4. R01 DC002260/NIDCD NIH HHS
  5. NS-34835/NINDS NIH HHS
  6. NS-10414/NINDS NIH HHS
  7. F32 NS010414/NINDS NIH HHS

MeSH Term

Animals
Auditory Cortex
Discrimination, Psychological
Haplorhini
Motivation
Neuronal Plasticity
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.
Article has an altmetric score of 1

Word Cloud

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