Strictly polyphosphate-dependent glucokinase in a polyphosphate-accumulating bacterium, Microlunatus phosphovorus.

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Shotaro Tanaka, Sun-Og Lee, Kazuhiro Hamaoka, Junichi Kato, Noboru Takiguchi, Kazunori Nakamura, Hisao Ohtake, Akio Kuroda

Author Information

Shotaro Tanaka: Department of Molecular Biotechnology, Hiroshima University, Hiroshima 739-8530, Japan.

PMID: 12949120 DOI: 10.1128/JB.185.18.5654-5656.2003

ATP-dependent glucokinase is suggested to have evolved from a hypothetical polyphosphate (polyP)-dependent glucokinase (polyP-GK) via a bifunctional polyP/ATP glucokinase (polyP/ATP-GK). Here we showed that polyP-GK is present in a polyP-accumulating bacterium, Microlunatus phosphovorus. The polyP-GK produced glucose-6-P(i) from glucose and polyP, but it could not phosphorylate glucose with ATP. The polyP-GK was most closely related to the polyP/ATP-GK of Mycobacterium tuberculosis.

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Adenosine Triphosphate

Amino Acid Sequence

Binding Sites

Glucokinase

Glucose-6-Phosphate

Molecular Sequence Data

Phosphorylation

Polyphosphates

Propionibacteriaceae

Sequence Homology, Amino Acid

Polyphosphates

Glucose-6-Phosphate

Adenosine Triphosphate

Glucokinase

Journal Article

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