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Molecular and cellular biochemistry
Nov, 2003;253 (1-2): 55-63.

Triclosan: a shot in the arm for antimalarial chemotherapy.

Satish P Ramachandra Rao, Avadhesha Surolia, Namita Surolia
Author Information
  1. Satish P Ramachandra Rao: Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
PMID: 14619956 DOI: 10.1023/a:1026049217966

Abstract

In order that malaria be successfully contained, it is important that one has a clear understanding of the normal physiology and biochemistry of the parasite essential to its survival in its human host. Until very recently, the conventional approaches to antimalarial chemotherapy have consistently been plagued with the uncanny ability of the parasite to evolve resistance to drugs. The recently discovered plasmodial fatty acid biosynthetic pathway as well as its inhibition by triclosan that classifies it as belonging to type II, provide with a very crucial breakthrough to the crusade against malaria. How triclosan could tilt the balance in favor of the human hosts of the malarial parasite in a malarial condition is discussed.

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MeSH Term

Animals
Antimalarials
Drug Resistance
Fatty Acids
Humans
Malaria
Protein Structure, Tertiary
Triclosan

Chemicals

Antimalarials
Fatty Acids
Triclosan
Journal Article Review

Word Cloud

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