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Current diabetes reports
Aug, 2004;4 (4): 247-52.

Oxidative stress and diabetic vascular complications.

Seok Man Son, Matthew K Whalin, David G Harrison, W Robert Taylor, Kathy K Griendling
Author Information
  1. Seok Man Son: Emory University School of Medicine, Division of Cardiology, 319 WMB, 1639 Pierce Drive, Atlanta, GA 30322, USA.
PMID: 15265465 DOI: 10.1007/s11892-004-0075-8

Abstract

Vascular complications of diabetes represent the leading cause of morbidity and mortality in affected patients. Production of reactive oxygen species is increased in diabetic patients, especially in those with poor glycemic control. Reactive oxygen species affect vascular smooth muscle cell growth and migration, endothelial function, including abnormal endothelium-dependent relaxation and expression of a proinflammatory phenotype, and modification of the extracellular matrix. All of these events contribute to the development of diabetic microvascular and macrovascular complications, suggesting that the sources of reactive oxygen species and the signaling pathways that they modify may represent important therapeutic targets.

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Grants

  1. T32 GM008169/NIGMS NIH HHS

MeSH Term

Animals
Diabetic Angiopathies
Humans
Oxidative Stress
Journal Article Review

Word Cloud

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