Role of flagellum and motility in pathogenesis of Vibrio vulnificus.
Jong-Ho Lee, Jong Bok Rho, Kyung-Je Park, Chang Beom Kim, Yang-Soo Han, Sang Ho Choi, Kyu-Ho Lee, Soon-Jung Park
Author Information
Jong-Ho Lee: Department of Parasitology and Institute of Tropical Medicine, BK21 Project for Medical Science, Yonsei University, Seoul 120-752, Korea.
To assess the role of the flagellum which was detected by immunoscreening of surface proteins of Vibrio vulnificus, an flgE-deleted mutant was constructed and tested for its pathogenicity. The ability of this nonmotile mutant to adhere to INT-407 cells and its role in biofilm were decreased, as was its lethality to mice.
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Animals
Bacterial Adhesion
Bacterial Proteins
Biofilms
Cell Line
Female
Flagella
Humans
Mice
Mice, Inbred ICR
Molecular Sequence Data
Movement
Mutation
Vibrio Infections
Vibrio vulnificus
Bacterial Proteins
FlgE protein, Bacteria
