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European child & adolescent psychiatry
2004;13 Suppl 1 I71-9.

Neuronal network models of ADHD -- lateralization with respect to interhemispheric connectivity reconsidered.

Veit Roessner, Tobias Banaschewski, Henrik Uebel, Andreas Becker, Aribert Rothenberger
Author Information
  1. Veit Roessner: University of Goettingen, Child and Adolescent Psychiatry, von-Siebold-Strasse 5, 37075, Goettingen, Germany. vroessn@gwdg.de
PMID: 15322958 DOI: 10.1007/s00787-004-1007-5

Abstract

BACKGROUND: Recent research on structural and functional anatomy related to ADHD has concentrated on fronto-striatocerebellar circuits. These findings and resultant neurobiological models of ADHD may explain some of the disturbances. On the other hand, there is some evidence that the restricted look at anterior-posterior anomalies might neglect the important additional information of lateralization problems related to hemispheric connectivity.
OBJECTIVE: Hence, the role of lateralization in the pathophysiology of ADHD should be reconsidered.
METHOD: After a short review of imaging studies in ADHD the special role of the corpus callosum (including the influence of its anomalies on general brain development, lateralization and functioning) is outlined and the first case of total agenesis of corpus callosum in a child with ADHD is presented and discussed within this context.
CONCLUSIONS: In view of the remaining inconsistencies concerning structural and functional brain anomalies in ADHD, attention should be paid not only to anterior- posterior but also to left-right aspects of functional and structural brain anomalies. This should include disturbances probably related to anomalies of the corpus callosum, especially in regard to co-existing problems like dyslexia and developmental coordination disorder.

References

  1. Ann Neurol. 1993 Jul;34(1):71-5 [PMID: 8517683]
  2. Life Sci. 2002 Mar 8;70(16):1909-22 [PMID: 12005176]
  3. Biol Psychiatry. 1999 Jun 15;45(12):1542-52 [PMID: 10376114]
  4. Am J Psychiatry. 1997 Aug;154(8):1051-6 [PMID: 9247388]
  5. Ann Neurol. 1997 Nov;42(5):705-11 [PMID: 9392569]
  6. Aust N Z J Psychiatry. 2001 Aug;35(4):504-11 [PMID: 11531733]
  7. Neurosci Biobehav Rev. 2000 Jan;24(1):13-9 [PMID: 10654655]
  8. Arch Neurol. 1991 Sep;48(9):933-6 [PMID: 1953417]
  9. J Child Neurol. 2002 Dec;17(12):877-84 [PMID: 12593459]
  10. Arch Neurol. 1990 Aug;47(8):919-26 [PMID: 2375699]
  11. Neurology. 1997 Mar;48(3):589-601 [PMID: 9065532]
  12. J Pers Assess. 1993 Apr;60(2):379-89 [PMID: 8473971]
  13. Am J Psychiatry. 1995 Jul;152(7):1105-6 [PMID: 7793463]
  14. Neurology. 2002 Jan 8;58(1):85-9 [PMID: 11781410]
  15. Neuroreport. 2000 Aug 3;11(11):2409-13 [PMID: 10943694]
  16. Prenat Diagn. 1995 Apr;15(4):301-12 [PMID: 7617572]
  17. Lancet. 2003 Nov 22;362(9397):1699-707 [PMID: 14643117]
  18. J Am Acad Child Adolesc Psychiatry. 1999 Nov;38(11):1363-71 [PMID: 10560222]
  19. World J Biol Psychiatry. 2002 Oct;3(4):216-20 [PMID: 12516313]
  20. Psychiatry Res. 2002 Nov 30;116(1-2):63-81 [PMID: 12426035]
  21. J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):374-83 [PMID: 9055518]
  22. Saudi Med J. 2001 Jan;22(1):22-5 [PMID: 11255605]
  23. J Comp Neurol. 1968 Jan;132(1):45-72 [PMID: 5293999]
  24. Cereb Cortex. 1997 Jan-Feb;7(1):48-56 [PMID: 9023431]
  25. J Child Neurol. 1990 Apr;5(2):127-30 [PMID: 2345279]
  26. J Child Neurol. 1996 Mar;11(2):112-5 [PMID: 8881987]
  27. Clin Neurophysiol. 2003 Nov;114(11):2036-42 [PMID: 14580601]
  28. Med Hypotheses. 2000 Aug;55(2):177-82 [PMID: 10904437]
  29. Biol Psychiatry. 1996 May 1;39(9):769-75 [PMID: 8731517]
  30. Cereb Cortex. 1994 Jul-Aug;4(4):331-43 [PMID: 7950307]
  31. Neuroreport. 2000 Feb 7;11(2):329-32 [PMID: 10674480]
  32. Neurol Res. 2001 Jul;23(5):465-71 [PMID: 11474802]
  33. Radiology. 1985 May;155(2):371-3 [PMID: 3983387]
  34. Prog Neuropsychopharmacol Biol Psychiatry. 1999 May;23(4):571-88 [PMID: 10390717]
  35. Neurosci Biobehav Rev. 2000 Jan;24(1):45-50 [PMID: 10654660]
  36. Nucl Med Commun. 2001 Dec;22(12 ):1333-40 [PMID: 11711904]
  37. Am J Psychiatry. 1994 May;151(5):665-9 [PMID: 8166306]
  38. Brain. 1989 Jun;112 ( Pt 3):799-835 [PMID: 2731030]
  39. Arch Neurol. 1997 Aug;54(8):963-8 [PMID: 9267970]
  40. Int J Psychiatry Med. 2003;33(1):107-13 [PMID: 12906349]
  41. Neuropsychology. 2003 Jul;17(3):496-506 [PMID: 12959515]
  42. Childs Nerv Syst. 2003 Aug;19(7-8):471-6 [PMID: 12845459]
  43. Neurosci Lett. 2003 Feb 27;338(2):91-4 [PMID: 12566160]
  44. J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):85-93 [PMID: 8429328]
  45. Arch Neurol. 1995 Aug;52(8):794-801 [PMID: 7639631]
  46. Rev Neurol. 2000 May 16-31;30(10):920-5 [PMID: 10919186]
  47. Arch Gen Psychiatry. 1998 Dec;55(12):1105-12 [PMID: 9862554]
  48. Biol Psychiatry. 2003 May 15;53(10):871-8 [PMID: 12742674]
  49. Epilepsy Behav. 2003 Dec;4(6):607-17 [PMID: 14698693]
  50. J Learn Disabil. 1991 Mar;24(3):141-6 [PMID: 2026955]
  51. Ann Neurol. 1998 May;43(5):608-12 [PMID: 9585354]
  52. J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):875-81 [PMID: 8083145]
  53. AJR Am J Roentgenol. 1993 May;160(5):949-55 [PMID: 8470609]
  54. Braz J Med Biol Res. 2003 Apr;36(4):409-20 [PMID: 12700818]
  55. Neurology. 1996 Aug;47(2):477-82 [PMID: 8757024]
  56. J Speech Lang Hear Res. 2001 Apr;44(2):246-63 [PMID: 11324649]
  57. Child Dev. 1996 Apr;67(2):523-40 [PMID: 8625726]
  58. Brain Lang. 2000 Jun 15;73(2):297-320 [PMID: 10856179]
  59. Arch Gen Psychiatry. 1996 Jul;53(7):607-16 [PMID: 8660127]
  60. J Am Acad Child Adolesc Psychiatry. 2003 Mar;42(3):303-10 [PMID: 12595783]
  61. J Am Acad Child Adolesc Psychiatry. 2002 Aug;41(8):990-8 [PMID: 12162635]
  62. Brain. 2000 Jul;123 ( Pt 7):1293-326 [PMID: 10869045]
  63. Dev Med Child Neurol. 2000 Jan;42(1):8-13 [PMID: 10665969]
  64. Biol Psychiatry. 2002 Oct 15;52(8):785-94 [PMID: 12372650]
  65. Am J Psychiatry. 1994 Dec;151(12):1791-6 [PMID: 7977887]
  66. Epilepsia. 1999 Feb;40(2):211-5 [PMID: 9952269]
  67. Biol Psychiatry. 1996 Nov 15;40(10):1060-3 [PMID: 8915567]
  68. Biol Res. 2003;36(1):89-99 [PMID: 12795208]

MeSH Term

Agenesis of Corpus Callosum
Attention Deficit Disorder with Hyperactivity
Central Nervous System Stimulants
Child
Electroencephalography
Functional Laterality
Humans
Magnetic Resonance Imaging
Male
Methylphenidate
Nerve Net
Severity of Illness Index

Chemicals

Central Nervous System Stimulants
Methylphenidate
Case Reports Journal Article Review

Word Cloud

Created with Highcharts 10.0.0ADHDanomalieslateralizationstructuralfunctionalrelatedcorpuscallosumbrainmodelsdisturbancesproblemsconnectivityrolereconsideredBACKGROUND:Recentresearchanatomyconcentratedfronto-striatocerebellarcircuitsfindingsresultantneurobiologicalmayexplainhandevidencerestrictedlookanterior-posteriormightneglectimportantadditionalinformationhemisphericOBJECTIVE:HencepathophysiologyMETHOD:shortreviewimagingstudiesspecialincludinginfluencegeneraldevelopmentfunctioningoutlinedfirstcasetotalagenesischildpresenteddiscussedwithincontextCONCLUSIONS:viewremaininginconsistenciesconcerningattentionpaidanterior-posterioralsoleft-rightaspectsincludeprobablyespeciallyregardco-existinglikedyslexiadevelopmentalcoordinationdisorderNeuronalnetwork--respectinterhemispheric

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