The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli.
Renaud Chollet, Jacqueline Chevalier, André Bryskier, Jean-Marie Pagès
Author Information
Renaud Chollet: Enveloppe Bactérienne, Perméabilité et Antibiotique, Faculté de Médecine, Université de la Méditerranée, Marseille, France.
The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine beta-naphthylamide, expel macrolides and telithromycin in E. aerogenes.
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Anti-Bacterial Agents
Arginine
Bacterial Outer Membrane Proteins
Dose-Response Relationship, Drug
Drug Resistance, Bacterial
Enterobacter aerogenes
Erythromycin
Escherichia coli
Escherichia coli Proteins
Ketolides
Macrolides
Membrane Transport Proteins
Microbial Sensitivity Tests
Anti-Bacterial Agents
Bacterial Outer Membrane Proteins
Escherichia coli Proteins
Ketolides
Macrolides
Membrane Transport Proteins
tolC protein, E coli
Erythromycin
arginine beta-naphthylamide
Arginine
telithromycin
