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Heart failure reviews
Apr, 2004;9 (2): 149-59.

Sex-related differences in heart failure and beta-blockers.

Jalal K Ghali
Author Information
  1. Jalal K Ghali: Clinical Research, Cardiac Centers of Louisiana, 2551 Greenwood Road, Suite 350, Shreveport, LA 71103, USA. jghali@arklatexcardio.net
PMID: 15516863 DOI: 10.1023/B:HREV.0000046370.81174.94

Abstract

Under-representation of women in heart failure trials has limited our knowledge of heart failure in women to extrapolation of findings from men. Significant sex related differences in clinical and laboratory characteristics exist in systolic heart failure including better survival in women. The value of various therapeutic interventions should be based on proven effect in women and not on an assumption based on proven benefit in men. Among the medications currently recommended for patients with systolic heart failure, beta-blockers have the strongest data supporting their efficacy in women.

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MeSH Term

Adrenergic beta-Antagonists
Angiotensin-Converting Enzyme Inhibitors
Female
Heart Failure
Hormone Replacement Therapy
Humans
Hypertrophy, Left Ventricular
Male
Sex Factors
Survival Analysis
Ventricular Dysfunction, Left
Ventricular Remodeling

Chemicals

Adrenergic beta-Antagonists
Angiotensin-Converting Enzyme Inhibitors
Journal Article Review

Word Cloud

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