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Behavioral neuroscience
Dec, 2004;118 (6): 1340-51.

Chronic oral estrogen affects memory and neurochemistry in middle-aged female mice.

Stephanie M Fernandez, Karyn M Frick
Author Information
  1. Stephanie M Fernandez: Department of Psychology, Yale University, New Haven, CT 06520, USA.
PMID: 15598143 DOI: 10.1037/0735-7044.118.6.1340

Abstract

This study tested whether chronic oral estrogen could improve memory and alter neural plasticity in the hippocampus and neocortex of middle-aged female mice. Ovariectomized C57BL/6 mice were administered 1,000, 1,500, or 2,500 nM 17beta-estradiol in drinking water for 5 weeks prior to and during spatial and object memory testing. Synaptophysin, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) levels were then measured in hippocampus and neocortex. The medium dose impaired spatial reference memory in the radial-arm maze, whereas all doses improved object recognition. The high dose increased hippocampal synaptophysin and NGF levels, whereas the medium dose decreased these neocortical levels. The high dose decreased neocortical BDNF levels. These data suggest that chronic oral estrogen selectively affects memory and neural function in middle-aged female mice.

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Grants

  1. R03 MH065460/NIMH NIH HHS
  2. MH065460/NIMH NIH HHS

MeSH Term

Administration, Oral
Animals
Behavior, Animal
Brain Chemistry
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Estradiol
Exploratory Behavior
Female
Frontal Lobe
Functional Laterality
Hippocampus
Maze Learning
Memory
Mice
Mice, Inbred C57BL
Nerve Growth Factors
Neuropsychological Tests
Organ Size
Ovariectomy
Recognition, Psychology
Synaptophysin
Uterus

Chemicals

Nerve Growth Factors
Synaptophysin
Estradiol
Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Word Cloud

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