Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides.
Barbara E Menzies, Aimee Kenoyer
Author Information
Barbara E Menzies: Veterans Affairs Puget Sound Health Care System, S-111-ID, 1660 S. Columbian Way, Seattle, WA 98108, USA. bmenzies@u.washington.edu
Keratinocytes upregulate expression of endogenous antimicrobial peptides in response to inflammatory stimuli. We show that both viable and heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of these peptides upon contact with human keratinocytes. The findings indicate a diversity of staphylococcal factors involved in upregulation of antimicrobial peptide expression in cutaneous epithelia.
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Antimicrobial Cationic Peptides
Epidermis
Humans
Keratinocytes
Lipopolysaccharides
Staphylococcal Infections
Staphylococcus aureus
Teichoic Acids
Antimicrobial Cationic Peptides
Lipopolysaccharides
Teichoic Acids
lipoteichoic acid
