Adherent biofilms in bacterial vaginosis.

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Alexander Swidsinski, Werner Mendling, Vera Loening-Baucke, Axel Ladhoff, Sonja Swidsinski, Laura P Hale, Herbert Lochs

Author Information

Alexander Swidsinski: Medizinische Klinik, Charité, CCM, Humboldt Universität, 10098 Berlin, Germany. alexander.swidsinski@charite.de

PMID: 16260520 DOI: 10.1097/01.AOG.0000183594.45524.d2

OBJECTIVE: Bacterial vaginosis is a common infectious disorder. Although known since ancient times, little progress has occurred in identifying causal factors. Our aims were to study the bacterial community structure and the spatial organization of microbiota on the epithelial surfaces of vaginal biopsy specimens.
METHODS: We investigated the composition and spatial organization of bacteria associated with the vaginal epithelium in biopsy specimens from 20 patients with Bacterial vaginosis and 40 normal premenopausal and postmenopausal controls using a broad range of fluorescent bacterial group-specific rRNA-targeted oligonucleotide probes.
RESULTS: Bacterial vaginosis was associated with greater occurrence and higher concentrations of a variety of bacterial groups. However, only Gardnerella vaginalis developed a characteristic adherent biofilm that was specific for Bacterial vaginosis.
CONCLUSION: A biofilm comprised of confluent G vaginalis with other bacterial groups incorporated in the adherent layer is a prominent feature of Bacterial vaginosis.
LEVEL OF EVIDENCE: II-2.

Adolescent

Adult

Bacterial Adhesion

Biofilms

Case-Control Studies

Child

Colony Count, Microbial

Epithelium

Female

Gram-Positive Bacteria

Humans

In Situ Hybridization, Fluorescence

Vagina

Vaginosis, Bacterial

Journal Article

Fighting polymicrobial biofilms in bacterial vaginosis.Bacterial Vaginosis-Vaginal Polymicrobial Biofilms and Dysbiosis.Dequalinium Chloride Effectively Disrupts Bacterial Vaginosis (BV) spp. Biofilms.Bacterial Vaginosis Biofilms: Challenges to Current Therapies and Emerging Solutions.Vaginal biofilms and bacterial vaginosis: of mice and women.Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora.Clue cells in bacterial vaginosis: immunofluorescent identification of the adherent gram-negative bacteria as Gardnerella vaginalis.[Bacterial vaginosis].Bacterial vaginosis.Bacterial vaginosis.

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