Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community.
Asa Bradman, Brenda Eskenazi, Dana B Barr, Roberto Bravo, Rosemary Castorina, Jonathan Chevrier, Katherine Kogut, Martha E Harnly, Thomas E McKone
Author Information
Asa Bradman: Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, California 94720-7380, USA. abradman@socrates.berkeley.edu
Little information has been published about pesticide exposures experienced by pregnant women. We measured six dialkyl phosphate (DAP) urinary metabolites of organophosphate (OP) pesticides in 600 pregnant, low-income women living in the Salinas Valley, California, an agricultural area. A total of 28% were employed as farm fieldworkers during pregnancy, and 81% had at least one household member who worked in agriculture. Samples were collected twice during pregnancy (mean = 13 and 26 weeks' gestation, respectively) and just after delivery (mean = 9 days). As in other studies, dimethyldithiophosphate levels were higher than those of other urinary OP metabolites. Total DAP metabolite levels in samples collected after delivery were higher than in samples collected during pregnancy. Median metabolite levels at the first and second prenatal sampling points and at the postpartum collection were 102.8, 106.8, and 227.2 nmol/L, respectively. Both prenatal and postpartum metabolite levels were higher in these Salinas Valley women than in a sample of women of childbearing age in the general U.S. population (National Health and Nutrition Examination Survey), although the deviation from U.S. reference levels was most pronounced after delivery. Higher DAP metabolite levels in the immediate postpartum period may have implications for estimating dose during pregnancy and for exposure during lactation.
References
J Expo Anal Environ Epidemiol. 2000 Mar-Apr;10(2):159-67
[PMID: 10791597]
Environ Health Perspect. 2003 Nov;111(14):1779-82
[PMID: 14594631]
Environ Res. 2000 Nov;84(3):290-302
[PMID: 11097803]
