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Antimicrobial agents and chemotherapy
Jan, 2006;50 (1): 365-7.

Clonal dissemination and mupA gene polymorphism of mupirocin-resistant Staphylococcus aureus isolates from long-term-care facilities in South Korea.

Jae Il Yoo, Eun Shim Shin, Jeong Ok Cha, Jeom Kyu Lee, Young Hee Jung, Kyeong Min Lee, Bong Su Kim, Yeong Seon Lee
Author Information
  1. Jae Il Yoo: Laboratory of Antimicrobial Resistant Pathogens, Department of Microbiology, National Institute of Health, KCDC, 194, Tonil-Lo, Eunpyung-Gu, Seoul 122-701, South Korea.
PMID: 16377713 DOI: 10.1128/AAC.50.1.365-367.2006

Abstract

We identified 25 high-level mupirocin-resistant (MuH) and 21 low-level mupirocin-resistant (MuL) Staphylococcus aureus isolates from eight long-term-care facilities (LTCFs). The pulsed-field gel electrophoresis patterns of 19 MuH and 19 MuL isolates from two facilities were identical for 18 and 15 isolates, respectively. The most predominant mupA restriction fragment length polymorphism type was found in 21 MuH isolates. We conclude that clonal transmission of MuH and MuL S. aureus strains occurred in these LTCFs. This is the first report of clonal transfer of mupirocin resistance in LTCFs.

References

  1. J Med Microbiol. 1993 Dec;39(6):450-3 [PMID: 8246264]
  2. Am J Med. 1993 Apr;94(4):371-8 [PMID: 8475930]
  3. Infect Control Hosp Epidemiol. 1994 Feb;15(2):69-70 [PMID: 8201234]
  4. Med J Aust. 1994 Sep 19;161(6):397-8 [PMID: 8090125]
  5. J Am Geriatr Soc. 1994 Oct;42(10):1062-9 [PMID: 7930330]
  6. Antimicrob Agents Chemother. 1994 Jul;38(7):1664-7 [PMID: 7979305]
  7. J Hosp Infect. 1995 Feb;29(2):153-5 [PMID: 7759832]
  8. Antimicrob Agents Chemother. 1995 Jun;39(6):1272-80 [PMID: 7574515]
  9. Antimicrob Agents Chemother. 1996 Dec;40(12):2820-3 [PMID: 9124848]
  10. Infect Control Hosp Epidemiol. 1996 Dec;17(12):811-3 [PMID: 8985769]
  11. J Med Microbiol. 1998 Sep;47(9):829-35 [PMID: 9736165]
  12. Am J Med. 1999 May 3;106(5A):2S-10S; discussion 48S-52S [PMID: 10348058]
  13. J Clin Microbiol. 1999 Sep;37(9):2781-8 [PMID: 10449452]
  14. Eur J Clin Microbiol Infect Dis. 1994 Jan;13(1):64-73 [PMID: 8168566]
  15. J Chemother. 1999 Oct;11(5):414-5 [PMID: 10632391]
  16. Clin Infect Dis. 2000 Dec;31(6):1414-22 [PMID: 11096012]
  17. Arch Intern Med. 2001 Mar 26;161(6):859-63 [PMID: 11268229]
  18. J Antimicrob Chemother. 2003 Mar;51(3):619-23 [PMID: 12615863]
  19. J Antimicrob Chemother. 2004 Jan;53(1):105-8 [PMID: 14657085]
  20. Infect Control Hosp Epidemiol. 1990 Jan;11(1):13-6 [PMID: 2105352]
  21. J Clin Microbiol. 1990 Mar;28(3):608-9 [PMID: 2108997]
  22. Lancet. 1990 May 5;335(8697):1095-6 [PMID: 1970392]

Grants

  1. /Intramural NIH HHS

MeSH Term

Anti-Bacterial Agents
Bacterial Proteins
Cross Infection
DNA, Bacterial
Drug Resistance, Bacterial
Humans
Korea
Long-Term Care
Mupirocin
Nuclear Proteins
Polymorphism, Genetic
Staphylococcal Infections
Staphylococcus aureus

Chemicals

Anti-Bacterial Agents
Bacterial Proteins
DNA, Bacterial
Nuclear Proteins
mupA protein, Staphylococcus aureus
Mupirocin
Journal Article Research Support, N.I.H., Intramural

Word Cloud

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