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The Journal of thoracic and cardiovascular surgery
Mar, 2006;131 (3): 579-586.e3.

The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study.

Julius M Guccione, Joseph C Walker, Jeremy R Beitler, Scott M Moonly, Peng Zhang, Michael A Guttman, Cengizhan Ozturk, Elliot R McVeigh, Arthur W Wallace, David A Saloner, Mark B Ratcliffe
Author Information
  1. Julius M Guccione: Department of Surgery, University of California, San Francisco, Calif, USA. Julius.Guccione@med.va.gov
PMID: 16515908 DOI: 10.1016/j.jtcvs.2005.07.065

Abstract

OBJECTIVES: Although repair of left ventricular aneurysm has been extensively studied, its effect on regional ventricular function remains unclear. The primary goal of this study was to quantify the effect of anteroapical aneurysm plication on systolic deformation in noninfarcted adjacent (border zone) and remote left ventricular regions in sheep.
METHODS: Eight sheep underwent anteroapical myocardial infarction (25% of left ventricular mass). Ten weeks later, animals underwent aneurysm plication. Two and 6 weeks after this operation, animals underwent magnetic resonance imaging with tissue tagging in multiple short-axis and long-axis slices. Fully 3-dimensional strain analyses were performed. All 6 end-systolic strain components were compared at midwall in the border zone of the aneurysm or repair and in regions 1 cm, 2 cm, and 3 cm below the valves.
RESULTS: Circumferential shortening progressively increases from before plication to 2 weeks after plication to 6 weeks after plication toward the border zone. The effect on circumferential shortening is most pronounced in the anterior wall and septum. The biggest change is from 2 to 6 weeks after plication (from 4.3% to 11.3% in anterior wall, P < .0001; from 3.5% to 6.5% in septum, P < .0007). Longitudinal shortening is decreased at 2 weeks after plication but then returns to baseline (with slight improvement in the border zone) at 6 weeks after plication.
CONCLUSIONS: Repair of left ventricular aneurysm significantly increases systolic circumferential shortening at the border zone in sheep.

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Grants

  1. R01-HL-63348/NHLBI NIH HHS
  2. R01 HL077921/NHLBI NIH HHS
  3. Z01 HL004608-08/Intramural NIH HHS
  4. R01-HL58759/NHLBI NIH HHS
  5. R01 HL063348/NHLBI NIH HHS

MeSH Term

Animals
Cardiac Surgical Procedures
Heart Aneurysm
Heart Ventricles
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Male
Myocardial Infarction
Sheep
Stroke Volume
Ventricular Dysfunction, Left
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Word Cloud

Created with Highcharts 10.0.0plicationweeksaneurysm6ventricularborderzonelefteffect2shorteninganteroapicalsheepunderwentstraincmrepairstudysystolicregionsanimalsmagneticresonanceimagingtaggingend-systolic3increasescircumferentialanteriorwallseptum3%P<5%OBJECTIVES:AlthoughextensivelystudiedregionalfunctionremainsunclearprimarygoalquantifydeformationnoninfarctedadjacentremoteMETHODS:Eightmyocardialinfarction25%massTenlaterTwooperationtissuemultipleshort-axislong-axisslicesFully3-dimensionalanalysesperformedcomponentscomparedmidwall1valvesRESULTS:Circumferentialprogressivelytowardpronouncedbiggestchange41100010007LongitudinaldecreasedreturnsbaselineslightimprovementCONCLUSIONS:Repairsignificantlythree-dimensionalsheep:

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