DNA replication fidelity: proofreading in trans.

Tina M Albertson, Bradley D Preston
Author Information
  1. Tina M Albertson: Department of Pathology, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA.

Abstract

Proofreading is the primary guardian of DNA polymerase fidelity. New work has revealed that polymerases with intrinsic proofreading activity may cooperate with non-proofreading polymerases to ensure faithful DNA replication.

MeSH Term

Animals
DNA
DNA Replication
DNA-Directed DNA Polymerase
Exonucleases
Models, Genetic
Mutation

Chemicals

DNA
DNA-Directed DNA Polymerase
Exonucleases

Word Cloud

Created with Highcharts 10.0.0DNApolymerasesproofreadingreplicationProofreadingprimaryguardianpolymerasefidelityNewworkrevealedintrinsicactivitymaycooperatenon-proofreadingensurefaithfulfidelity:trans

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