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Journal of clinical microbiology
Aug, 2006;44 (8): 3021-4.

False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria.

Anne F Gasasira, Grant Dorsey, Moses R Kamya, Diane Havlir, Moses Kiggundu, Philip J Rosenthal, Edwin D Charlebois
Author Information
  1. Anne F Gasasira: Department of Medicine, Makerere University Medical School, Kampala, Uganda.
PMID: 16891532 DOI: 10.1128/JCM.02207-05

Abstract

Malaria may impact upon human immunodeficiency virus (HIV) test results. We evaluated two HIV enzyme immunoassays (EIAs) by testing 1,965 Ugandans with malaria. We found poor positive predictive values (53% and 76%), particularly with younger age. Combining EIAs eliminated false positives but missed 21% of true positives. Performance of HIV EIAs in malaria may be unsatisfactory.

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Grants

  1. U01 AI062677/NIAID NIH HHS
  2. AI62677/NIAID NIH HHS

MeSH Term

AIDS Serodiagnosis
Age Factors
False Positive Reactions
HIV Infections
Humans
Immunoenzyme Techniques
Malaria
Predictive Value of Tests
Uganda
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.
Article has an altmetric score of 10

Word Cloud

Created with Highcharts 10.0.0HIVEIAsmalariamayhumanimmunodeficiencyvirusresultsenzymeimmunoassayspositivesMalariaimpactupontestevaluatedtwotesting1965Ugandansfoundpoorpositivepredictivevalues53%76%particularlyyoungerageCombiningeliminatedfalsemissed21%truePerformanceunsatisfactoryFalse-positivepatientsuncomplicated

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