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Proceedings of the National Academy of Sciences of the United States of America
Oct 24, 2006;103 (43): 15911-5.

Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase.

Karen D Williams, Macarena Busto, Maximiliano L Suster, Anthony K-C So, Yehuda Ben-Shahar, Sally J Leevers, Marla B Sokolowski
Author Information
  1. Karen D Williams: Department of Biology, University of Toronto, 3359 Mississauga Road, Mississauga, ON, Canada L5L 1C6.
PMID: 17043223 DOI: 10.1073/pnas.0604592103

Abstract

This study links natural variation in a Drosophila melanogaster overwintering strategy, diapause, to the insulin-regulated phosphatidylinositol 3-kinase (PI3-kinase) gene, Dp110. Variation in diapause, a reproductive arrest, was associated with Dp110 by using Dp110 deletions and genomic rescue fragments in transgenic flies. Deletions of Dp110 increased the proportion of individuals in diapause, whereas expression of Dp110 in the nervous system, but not including the visual system, decreased it. The roles of phosphatidylinositol 3-kinase for both diapause in D. melanogaster and dauer formation in Caenorhabditis elegans suggest a conserved role for this kinase in both reproductive and developmental arrests in response to environmental stresses.

Associated Data

GENBANK | DQ792599; DQ792600

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MeSH Term

Animals
Behavior, Animal
Drosophila melanogaster
Gene Dosage
Genetic Variation
Insulin
Molecular Sequence Data
Neurons
Phenotype
Phosphatidylinositol 3-Kinases
Sequence Analysis, DNA
Sequence Analysis, RNA

Chemicals

Insulin
Phosphatidylinositol 3-Kinases
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

Created with Highcharts 10.0.0diapauseDp110melanogastervariationDrosophilainsulin-regulatedphosphatidylinositol3-kinasePI3-kinasereproductivesystemstudylinksnaturaloverwinteringstrategygeneVariationarrestassociatedusingdeletionsgenomicrescuefragmentstransgenicfliesDeletionsincreasedproportionindividualswhereasexpressionnervousincludingvisualdecreasedrolesDdauerformationCaenorhabditiseleganssuggestconservedrolekinasedevelopmentalarrestsresponseenvironmentalstressesNaturaldue

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