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Hearing research
Apr, 2007;226 (1-2): 22-43.

Mechanisms of noise-induced hearing loss indicate multiple methods of prevention.

Colleen G Le Prell, Daisuke Yamashita, Shujiro B Minami, Tatsuya Yamasoba, Josef M Miller
Author Information
  1. Colleen G Le Prell: Kresge Hearing Research Institute, University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506, USA. colleeng@umich.edu
PMID: 17141991 DOI: 10.1016/j.heares.2006.10.006

Abstract

Recent research has shown the essential role of reduced blood flow and free radical formation in the cochlea in noise-induced hearing loss (NIHL). The amount, distribution, and time course of free radical formation have been defined, including a clinically significant late formation 7-10 days following noise exposure, and one mechanism underlying noise-induced reduction in cochlear blood flow has finally been identified. These new insights have led to the formulation of new hypotheses regarding the molecular mechanisms of NIHL; and, from these, we have identified interventions that prevent NIHL, even with treatment onset delayed up to 3 days post-noise. It is essential to now assess the additive effects of agents intervening at different points in the cell death pathway to optimize treatment efficacy. Finding safe and effective interventions that attenuate NIHL will provide a compelling scientific rationale to justify human trials to eliminate this single major cause of acquired hearing loss.

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Grants

  1. R01 DC004058/NIDCD NIH HHS
  2. R01 DC003820-01A2/NIDCD NIH HHS
  3. P30 DC005188-01A1/NIDCD NIH HHS
  4. P30 DC005188/NIDCD NIH HHS
  5. R01 DC003820/NIDCD NIH HHS
  6. R01 DC03820/NIDCD NIH HHS

MeSH Term

Animals
Antioxidants
Auditory Threshold
Calcium
Cell Death
Cochlea
Dexamethasone
Free Radicals
Glutamic Acid
Hearing Loss, Noise-Induced
Humans
Models, Biological
Nerve Growth Factors
Reactive Nitrogen Species
Vasodilation

Chemicals

Antioxidants
Free Radicals
Nerve Growth Factors
Reactive Nitrogen Species
Glutamic Acid
Dexamethasone
Calcium
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review
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