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Genetics
Apr, 2007;175 (4): 1855-67.

Evolution of the male-determining gene SRY within the cat family Felidae.

V King, P N Goodfellow, A J Pearks Wilkerson, W E Johnson, S J O'Brien, J Pecon-Slattery
Author Information
  1. V King: Department of Genetics, University of Cambridge, Cambridge, CB2 3EH, United Kingdom.
PMID: 17277366 DOI: 10.1534/genetics.106.066779

Abstract

In most placental mammals, SRY is a single-copy gene located on the Y chromosome and is the trigger for male sex determination during embryonic development. Here, we present comparative genomic analyses of SRY (705 bp) along with the adjacent noncoding 5' flank (997 bp) and 3' flank (948 bp) in 36 species of the cat family Felidae. Phylogenetic analyses indicate that the noncoding genomic flanks and SRY closely track species divergence. However, several inconsistencies are observed in SRY. Overall, the gene exhibits purifying selection to maintain function (omega = 0.815) yet SRY is under positive selection in two of the eight felid lineages. SRY has low numbers of nucleotide substitutions, yet most encode amino acid changes between species, and four different species have significantly altered SRY due to insertion/deletions. Moreover, fixation of nonsynonymous substitutions between sister taxa is not consistent and may occur rapidly, as in the case of domestic cat, or not at all over long periods of time, as observed within the Panthera lineage. The former resembles positive selection during speciation, and the latter purifying selection to maintain function. Thus, SRY evolution in cats likely reflects the different phylogeographic histories, selection pressures, and patterns of speciation in modern felids.

Associated Data

GENBANK | DQ095160; DQ095161; DQ095162; DQ095163; DQ095164; DQ095165; DQ095166; DQ095167; DQ095168; DQ095169; DQ095170; DQ095171; DQ095172; DQ095173; DQ095174; DQ095175; DQ095176; DQ095177; DQ095178; DQ095179; DQ095180; DQ095181; DQ095182; DQ095183; DQ095184; DQ095185; DQ095186; DQ095187; DQ095188; DQ095189; DQ095190; DQ095191; DQ095192; DQ095193; DQ095194; DQ095195

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Grants

  1. /Wellcome Trust
  2. N01CO12400/NCI NIH HHS
  3. /Intramural NIH HHS
  4. N01-CO-12400/NCI NIH HHS

MeSH Term

3' Flanking Region
5' Flanking Region
Amino Acid Sequence
Amino Acid Substitution
Animals
Cats
DNA
Evolution, Molecular
Felidae
Genes, sry
Male
Models, Genetic
Molecular Sequence Data
Phylogeny
Selection, Genetic
Sequence Homology, Amino Acid
Sex Determination Processes
Sex-Determining Region Y Protein
Species Specificity

Chemicals

Sex-Determining Region Y Protein
DNA
Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't
Article has an altmetric score of 3

Word Cloud

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