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Journal of neural transmission (Vienna, Austria : 1996)
2007;114 (8): 1033-9.

Platelet phospholipase A2 activity in patients with Alzheimer's disease, vascular dementia and ischemic stroke.

E Krzystanek, M Krzystanek, G Opala, H I Trzeciak, J Siuda, A Małecki
Author Information
  1. E Krzystanek: Department of Late Age Neurology, Silesian Medical University, Katowice, Poland. ewa26@mp.pl
PMID: 17447002 DOI: 10.1007/s00702-007-0669-9

Abstract

Phospholipase A(2) (E.C. 3.1.1.4, PLA(2)) plays an essential role in metabolism of membrane phospholipids, it is related to inflammatory reactions, secretion of amyloid precursor protein and activation of NMDA receptor after ischemia. In the present study we investigated PLA(2) activity in platelets from 37 Alzheimer's disease (AD) patients, 32 vascular dementia (VaD) patients and 32 individuals with ischemic stroke as compared to 27 healthy elderly controls. PLA(2) activity was determined using radiometric assay. Mean platelet PLA(2) activity was increased in individuals with Alzheimer's disease (p < 0.001). In VaD group the enzyme activity was between the values in AD and controls, these differences being significant from both groups. In the group of patients with ischemic stroke mean PLA(2) activity was higher either 48 h after the stroke or 7 days later (in both cases p < 0.001). The results may be particularly interesting in light of the fact, that inhibitors of PLA(2) activity are known.

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MeSH Term

Aged
Aged, 80 and over
Alzheimer Disease
Amyloid beta-Peptides
Biomarkers
Blood Platelets
Brain
Brain Ischemia
Dementia, Vascular
Encephalitis
Female
Group II Phospholipases A2
Humans
Male
Membrane Lipids
Receptors, N-Methyl-D-Aspartate
Stroke
Up-Regulation

Chemicals

Amyloid beta-Peptides
Biomarkers
Membrane Lipids
Receptors, N-Methyl-D-Aspartate
Group II Phospholipases A2
Journal Article

Word Cloud

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