Delay discounting in schizophrenia.

Erin A Heerey, Benjamin M Robinson, Robert P McMahon, James M Gold
Author Information
  1. Erin A Heerey: Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD, USA. e.heerey@bangor.ac.uk

Abstract

BACKGROUND: It is well known that individuals with schizophrenia have dopaminergic abnormalities as well as memory-related difficulties, both of which are associated with impulsive decision making. We used a delay discounting measure to test the degree to which patients make future-oriented decisions.
METHODS: 42 patients with schizophrenia and 29 healthy participants completed a delay discounting measure along with tests of cognitive function and, in patients, symptom ratings.
RESULTS: Patients discounted more steeply than did comparison participants. Discounting among patients related to memory capacity and tended to relate inversely to negative symptoms.
CONCLUSIONS: The impulsive decision making evidenced by patients suggests that they may be prone to choosing immediate over long-term rewards, even when their interests are better served by choosing the latter. Improving cognitive function may enhance their ability to make future-oriented decisions.

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Grants

  1. R01 MH080066/NIMH NIH HHS
  2. R01 MH080066-04/NIMH NIH HHS
  3. R24 MH072647/NIMH NIH HHS
  4. MH72647/NIMH NIH HHS

MeSH Term

Adult
Cognition Disorders
Decision Making
Diagnostic and Statistical Manual of Mental Disorders
Disruptive, Impulse Control, and Conduct Disorders
Dopamine
Female
Humans
Male
Neuropsychological Tests
Reward
Schizophrenia
Severity of Illness Index
Surveys and Questionnaires
Time Factors
Time Perception

Chemicals

Dopamine

Word Cloud

Created with Highcharts 10.0.0patientsschizophreniadiscountingwellimpulsivedecisionmakingdelaymeasuremakefuture-orienteddecisionsparticipantscognitivefunctionmaychoosingBACKGROUND:knownindividualsdopaminergicabnormalitiesmemory-relateddifficultiesassociatedusedtestdegreeMETHODS:4229healthycompletedalongtestssymptomratingsRESULTS:PatientsdiscountedsteeplycomparisonDiscountingamongrelatedmemorycapacitytendedrelateinverselynegativesymptomsCONCLUSIONS:evidencedsuggestsproneimmediatelong-termrewardseveninterestsbetterservedlatterImprovingenhanceabilityDelay

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